α-Synuclein aggregation causes muscle atrophy through neuromuscular junction degeneration

α-Synuclein aggregation causes muscle atrophy through neuromuscular junction degeneration
J Cachexia Sarcopenia Muscle. 2022 Nov 23. doi: 10.1002/jcsm.13123. Online ahead of print.ABSTRACTBACKGROUND: Sarcopenia is common in patients with Parkinson's disease (PD), showing mitochondrial oxidative stress in skeletal muscle. The aggregation of α-synuclein (α-Syn) to induce oxidative stress is a key pathogenic process of PD; nevertheless, we know little about its potential role in regulating peripheral nerves and the function ... read more
Source: PubMedPublished on 2022-11-23By Qiumei Yang