α-Synuclein Induced the Occurrence of RBD via Interaction with OX1R and Modulated Its Degradation

α-Synuclein Induced the Occurrence of RBD via Interaction with OX1R and Modulated Its Degradation
Neuromolecular Med. 2023 Jan 23. doi: 10.1007/s12017-023-08735-4. Online ahead of print.ABSTRACTRapid eye movement (REM) sleep behavior disorder (RBD) is a powerful early sign of Parkinson's disease (PD), but the pathogenetic mechanism involved in RBD remains largely unexplored. α-Synuclein has been verified to form Lewy bodies in the orexin neurons, whose activity and function rely on the orexin 1 receptor (OX1R). ... read more
Source: PubMedPublished on 2023-01-23By Jing Kai Fan