α-Synuclein Seed Amplification Assays for Diagnosing Synucleinopathies: The Way Forward

α-Synuclein Seed Amplification Assays for Diagnosing Synucleinopathies: The Way Forward
Neurology. 2022 Aug 2;99(5):195-205. doi: 10.1212/WNL.0000000000200878. Epub 2022 Jun 3.ABSTRACTParkinson disease (PD) is the second most common neurodegenerative disease, and the most common synucleinopathy, as alpha-synuclein (α-syn), a prion-like protein, plays an important pathophysiologic role in its onset and progression. Although neuropathologic changes begin many years before the onset of motor manifestations, diagnosis still relies on the identification of the ... read more
Source: PubMedPublished on 2022-08-01By Giovanni Bellomo