α-Synuclein Up-regulates Monoamine Oxidase A Expression and Activity via Trans-Acting Transcription Factor 1

α-Synuclein Up-regulates Monoamine Oxidase A Expression and Activity via Trans-Acting Transcription Factor 1
Front Aging Neurosci. 2021 Mar 17;13:653379. doi: 10.3389/fnagi.2021.653379. eCollection 2021.ABSTRACTAbnormal α-Synuclein (α-SYN) aggregates are the pathological hallmarks of Parkinson's disease (PD), which may affect dopamine (DA) neuron function and DA metabolism. Monoamine oxidase A (MAOA) is an enzyme located on the outer mitochondrial membrane that catalyzes the oxidative deamination of DA. Both α-SYN and MAOA are associated with PD pathogenesis, ... read more
Source: PubMedPublished on 2021-04-05By Congcong Jia