5-HT1B receptor-AC-PKA signal pathway in the lateral habenula is involved in the regulation of depressive-like behaviors in 6-hydroxydopamine-induced Parkinson’s rats

5-HT1B receptor-AC-PKA signal pathway in the lateral habenula is involved in the regulation of depressive-like behaviors in 6-hydroxydopamine-induced Parkinson’s rats
Neurol Res. 2022 Sep 20:1-11. doi: 10.1080/01616412.2022.2124797. Online ahead of print.ABSTRACTOBJECTIVE: The aim of the present study was to investigate whether serotonin1B (5-HT1B) receptor-adenylate cyclase (AC)-protein kinase A (PKA) signal pathway in the lateral habenula (LHb) is involved in Parkinson's disease-related depression in sham-lesioned and substantia nigra pars compacta (SNc)-lesioned rats.METHODS: The sucrose preference and forced swim tests were used ... read more
Source: PubMedPublished on 2022-09-20By Guo Yi Tang