A 10-Year Community-Based Study of Leucine-Rich Repeat Kinase 2 G2385R Carriers’ Conversion to Parkinson’s Disease

A 10-Year Community-Based Study of Leucine-Rich Repeat Kinase 2 G2385R Carriers’ Conversion to Parkinson’s Disease
Mov Disord. 2022 Jun 22. doi: 10.1002/mds.29127. Online ahead of print.ABSTRACTBACKGROUND: The G2385R variant of leucine-rich repeat kinase 2 (LRRK2) is mainly associated with Parkinson's disease(PD) in Asian populations.OBJECTIVE: The aim of this study was to investigate the PD conversion rate and clinical characteristics of LRRK2 G2385R nonmanifesting carriers.METHODS: All participants were from the community-based longitudinal cohort of Shanghai Ruijin ... read more
Source: PubMedPublished on 2022-06-23By Pei Wang