A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation

A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation
Elife. 2022 Sep 23;11:e79771. doi: 10.7554/eLife.79771. Online ahead of print.ABSTRACTActivating mutations in the Leucine Rich Repeat Kinase 2 (LRRK2) cause Parkinson's disease and previously we showed that activated LRRK2 phosphorylates a subset of Rab GTPases (Steger et al., 2017). Moreover, Golgi-associated Rab29 can recruit LRRK2 to the surface of the Golgi and activate it there for both auto- and Rab ... read more
Source: PubMedPublished on 2022-09-23By Edmundo G Vides