Acquisition and processing of high-speed atomic force microscopy videos for single amyloid aggregate observation

Acquisition and processing of high-speed atomic force microscopy videos for single amyloid aggregate observation
Methods. 2021 Jun 6:S1046-2023(21)00158-4. doi: 10.1016/j.ymeth.2021.06.006. Online ahead of print.ABSTRACTThe structural dynamics of the amyloid protein aggregation process are associated with neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. High-speed atomic force microscopy (HS-AFM) is able to visualize the structural dynamics of individual aggregate species that otherwise cannot be distinguished. HS-AFM observations also detect impurities in the sample, and thus, ... read more
Source: PubMedPublished on 2021-06-09By Takahiro Watanabe-Nakayama