Source: Google NewsPublished on 2020-12-22
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- PARP-kinson’s goes chlorogenic December 20, 2020 # # # # For a long time it was been reported that coffee may be able to reduce the risk of developing Parkinson’s, but the mechansim by which this association could be occurring has remained elusive. Now researchers from South Korea have discovered a biological pathway that could help to explain the protective association. It involves a protein called…
- Activation of the Akt1-CREB pathway promotes RNF146 expression to inhibit PARP1-mediated neuronal death. January 15, 2021 Related ArticlesActivation of the Akt1-CREB pathway promotes RNF146 expression to inhibit PARP1-mediated neuronal death. Sci Signal. 2020 Dec 22;13(663): Authors: Kim H, Park J, Kang H, Yun SP, Lee YS, Lee YI, Lee Y Abstract Progressive degeneration of dopaminergic neurons characterizes Parkinson's disease (PD). This neuronal loss occurs through diverse mechanisms, including a form of programmed cell death dependent on…
- Rhododendrin-Induced RNF146 Expression via Estrogen Receptor β Activation is Cytoprotective Against 6-OHDA-Induced Oxidative Stress. April 13, 2019 Related ArticlesRhododendrin-Induced RNF146 Expression via Estrogen Receptor β Activation is Cytoprotective Against 6-OHDA-Induced Oxidative Stress. Int J Mol Sci. 2019 Apr 10;20(7): Authors: Kim H, Park J, Leem H, Cho M, Yoon JH, Maeng HJ, Lee Y Abstract Ring finger protein 146 (RNF146) is an E3 ubiquitin ligase whose activity prevents poly (ADP-ribose) polymerase 1 (PARP1)-dependent neurodegeneration in Parkinson's disease…
- Monthly Research Review – December 2020 December 31, 2020 At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during December 2020. The post is divided into seven parts based on the type of research: Basic biology Disease mechanism Clinical research New clinical trials Clinical trial news Conferences/lectures Other news…
- Monthly research review: February 2020 February 29, 2020 At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during February 2020. The post is divided into seven parts based on the type of research: Basic biology Disease mechanism Clinical research New clinical trials Clinical trial news Other news Review…
- 2020: Year in Review January 1, 2021 # # # # In this end-of-year post, we review the Parkinson’s research that caught our attention at SoPD HQ in 2020. Month-by-month we will briefly discuss some of the major pieces of research/ announcements that have defined the year and advanced our understanding of Parkinson’s. The list is based on nothing more than the author’s personal opinion – apologies…
- Monthly Research Review – November 2019 November 30, 2019 At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during November 2019. The post is divided into seven parts based on the type of research: Basic biology Disease mechanism Clinical research New clinical trials Clinical trial news Other news Review…
- Monthly research review – October 2019 October 31, 2019 At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during October 2019. The post is divided into seven parts based on the type of research: Basic biology Disease mechanism Clinical research New clinical trials Clinical trial news Other news Review…
- Monthly Research Review – November 2020 November 30, 2020 At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during November 2020. The post is divided into seven parts based on the type of research: Basic biology Disease mechanism Clinical research New clinical trials Clinical trial news Conferences/lectures Other news…
- Monthy research review – December 2019 December 30, 2019 At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during December 2019. The post is divided into seven parts based on the type of research: Basic biology Disease mechanism Clinical research New clinical trials Clinical trial news Other news Review…
- Cinnamon and its Metabolite Protect the Nigrostriatum in a Mouse Model of Parkinson's Disease Via Astrocytic GDNF. May 24, 2019 Related ArticlesCinnamon and its Metabolite Protect the Nigrostriatum in a Mouse Model of Parkinson's Disease Via Astrocytic GDNF. J Neuroimmune Pharmacol. 2019 May 22;: Authors: Patel D, Jana A, Roy A, Pahan K Abstract Glial cell line-derived neurotrophic factor (GDNF) has potent neurotrophic effects and is known to promote the dopaminergic (DA) neuronal survival in cellular and animal models of…
- Basal Ganglia, Nigrostriatal Pathway and Parkinson’s May 12, 2020 “Hope arouses, as nothing else can arouse, a passion for the possible.” William Sloane Coffin “Walk on, walk on with hope in your heart, and you’ll never walk alone, you’ll never walk alone.” Oscar Hammerstein II Introduction: I have been trying to learn more about brain physiology and the inner workings as it relates to Parkinson’s. To do this, the…
- Basal Ganglia, Nigrostriatal Pathway and Parkinson’s May 12, 2020 “Hope arouses, as nothing else can arouse, a passion for the possible.” William Sloane Coffin “Walk on, walk on with hope in your heart, and you’ll never walk alone, you’ll never walk alone.” Oscar Hammerstein II Introduction: I have been trying to learn more about brain physiology and the inner workings as it relates to Parkinson’s. To do this, the…
- Basal Ganglia, Nigrostriatal Pathway and Parkinson’s May 12, 2020 “Hope arouses, as nothing else can arouse, a passion for the possible.” William Sloane Coffin “Walk on, walk on with hope in your heart, and you’ll never walk alone, you’ll never walk alone.” Oscar Hammerstein II Introduction: I have been trying to learn more about brain physiology and the inner workings as it relates to Parkinson’s. To do this, the…
- Monthly Research Review – August 2019 August 31, 2019 At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during August 2019. The post is divided into seven parts based on the type of research: Basic biology Disease mechanism Clinical research New clinical trials Clinical trial news Other news Review…
- Researchers Find Pathway Responsible for Nerve Cell Death in Parkinson’s Disease November 7, 2018 Johns Hopkins researchers have identified a specific cell death pathway named Parthanatos — after Thanatos, the ancient Greek personification of death — that leads to the physical and intellectual degeneration associated with Parkinson’s disease. They also found that a protein called PARP-1 is a key mediator of cell death via Parthanatos, supporting the potential therapeutic benefits of PARP inhibitors for halting Parkinson’s progression. “Nailing…
- Monthly Research Review – September 2019 September 30, 2019 At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during September 2019. The post is divided into seven parts based on the type of research: Basic biology Disease mechanism Clinical research New clinical trials Clinical trial news Other news Review…
- Manganese-induced Parkinsonism Compared to Parkinson’s Disease July 25, 2019 “Science is a way of thinking much more than it is a body of knowledge.” Carl Sagan “Imagination is more important than knowledge.” Albert Einstein What is Manganese? Manganese is abbreviated by the symbol Mn and it is atomic number 25 (see Periodic Table of the Elements). Manganese is considered a transition metal, which is important for industrial alloys like…
- Sleep Pathway May Be Linked to Neurodegenerative Diseases, Study Shows March 19, 2020 An important signaling pathway that helps protect brain cells from neurodegenerative diseases such as Parkinson’s disease is also required for sleep in fruit flies and zebrafish, according to a study. The findings support a link between sleep loss and neurodegenerative diseases. As this mechanism was found in two distantly related species, it may exist in humans, which would support new…
- Neuroprotection with Taurine in a Parkinson’s Model System April 5, 2018 “There is no medicine like hope, no incentive so great, and no tonic so powerful as expectation of something tomorrow.” Orison Swett Marden “Hope sees the invisible, feels the intangible, and achieves the impossible.” Helen Keller Introduction: Many of us take levodopa/carbidopa for substantial symptomatic relief; however, this dopamine replacement treatment only relieves symptoms without offering either neuroprotection or neuro-restoration.…
- Microglia activation induces oxidative injury and decreases SIRT3 expression in dopaminergic neuronal cells. April 21, 2019 Related ArticlesMicroglia activation induces oxidative injury and decreases SIRT3 expression in dopaminergic neuronal cells. J Neural Transm (Vienna). 2019 Apr 19;: Authors: Jiang DQ, Ma YJ, Wang Y, Lu HX, Mao SH, Zhao SH Abstract Microglia activation-mediated neuroinflammation plays an important role in the progression of Parkinson's disease (PD). However, effects of microglia activation on dopaminergic neuronal cell (DAC) fate…
- ERRγ ligand HPB2 upregulates BDNF-TrkB and enhances dopaminergic neuronal phenotype. January 13, 2021 Related ArticlesERRγ ligand HPB2 upregulates BDNF-TrkB and enhances dopaminergic neuronal phenotype. Pharmacol Res. 2021 Jan 09;:105423 Authors: Kim HI, Lee S, Lim J, Chung S, Koo TS, Ji YG, Suh YG, Son WS, Kim SH, Choi HJ Abstract Brain derived neurotrophic factor (BDNF) promotes maturation of dopaminergic (DAergic) neurons in the midbrain and positively regulates their maintenance and outgrowth. Therefore,…