alpha-Synuclein pathology in Parkinson disease activates homeostatic NRF2 anti-oxidant response

alpha-Synuclein pathology in Parkinson disease activates homeostatic NRF2 anti-oxidant response
Acta Neuropathol Commun. 2021 Jun 6;9(1):105. doi: 10.1186/s40478-021-01209-3.ABSTRACTCircumstantial evidence points to a pathological role of alpha-synuclein (aSyn; gene symbol SNCA), conferred by aSyn misfolding and aggregation, in Parkinson disease (PD) and related synucleinopathies. Several findings in experimental models implicate perturbations in the tissue homeostatic mechanisms triggered by pathological aSyn accumulation, including impaired redox homeostasis, as significant contributors in the pathogenesis ... read more
Source: PubMedPublished on 2021-06-07By Alberto Delaidelli