ALS- and FTD-associated missense mutations in TBK1 differentially disrupt mitophagy

ALS- and FTD-associated missense mutations in TBK1 differentially disrupt mitophagy
Proc Natl Acad Sci U S A. 2021 Jun 15;118(24):e2025053118. doi: 10.1073/pnas.2025053118.ABSTRACTTANK-binding kinase 1 (TBK1) is a multifunctional kinase with an essential role in mitophagy, the selective clearance of damaged mitochondria. More than 90 distinct mutations in TBK1 are linked to amyotrophic lateral sclerosis (ALS) and fronto-temporal dementia, including missense mutations that disrupt the abilities of TBK1 to dimerize, associate ... read more
Source: PubMedPublished on 2021-06-08By Olivia Harding