Altered functional connectivity of the marginal division in Parkinson’s disease with mild cognitive impairment: A pilot resting-state fMRI study – MD Linx

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• Better Biomarkers Needed to Diagnose, Predict Risk of Mild Cognitive Impairment March 15, 2018 There still are no reliable biomarkers for early detection, or to characterize and predict risk of dementia, in Parkinson’s disease, according to a recent analysis. Several studies on the cognitive deficits, progression to dementia, potential biomarkers and the mechanisms underlying Parkinson’s disease mild cognitive impairment (PD-MCI) were analyzed by University College London researchers in the review study “Mild Cognitive Impairment in…
• Mild Cognitive Impairment in Parkinson’s Linked to Worse Memory, Attention Deficits, Study Reports April 3, 2019 Parkinson’s disease patients with mild cognitive impairment (MCI) have a lower quality of life if their memory is impaired, according to a study that also revealed that MCI is associated with more severe attention and memory dysfunction in people with the disease. The study, “Mild cognitive impairment in Parkinson’s disease: Characterization and impact on quality of life according to subtype,”…
• DBS: location, location, location December 15, 2019   Deep brain stimulation (or DBS) represents a well established treatment option for individuals with Parkinson’s who no longer respond to standard therapies. It involves tiny electrodes being embedded in the brain and they modulate populations of neurons that have become dysfunctional. The results of the DBS procedure can be “miraculous” for some individuals – reducing tremors and significantly improving…
• L-Dopa Modulation of Brain Connectivity in Parkinson's Disease Patients: A Pilot EEG-fMRI Study. July 2, 2019 L-Dopa Modulation of Brain Connectivity in Parkinson's Disease Patients: A Pilot EEG-fMRI Study. Front Neurosci. 2019;13:611 Authors: Evangelisti S, Pittau F, Testa C, Rizzo G, Gramegna LL, Ferri L, Coito A, Cortelli P, Calandra-Buonaura G, Bisquoli F, Bianchini C, Manners DN, Talozzi L, Tonon C, Lodi R, Tinuper P Abstract Studies of functional neurosurgery and electroencephalography in Parkinson's disease have…
• A study of neural activity and functional connectivity within the olfactory brain network in Parkinson's disease. September 8, 2019 Related ArticlesA study of neural activity and functional connectivity within the olfactory brain network in Parkinson's disease. Neuroimage Clin. 2019;23:101946 Authors: Georgiopoulos C, Witt ST, Haller S, Dizdar N, Zachrisson H, Engström M, Larsson EM Abstract Olfactory dysfunction is an early manifestation of Parkinson's disease (PD). The present study aimed to illustrate potential differences between PD patients and healthy controls…
• Why Is Aging a Risk Factor for Cognitive Impairment in Parkinson's Disease?-A Resting State fMRI Study. April 11, 2019 Related ArticlesWhy Is Aging a Risk Factor for Cognitive Impairment in Parkinson's Disease?-A Resting State fMRI Study. Front Neurol. 2019;10:267 Authors: Nagano-Saito A, Bellec P, Hanganu A, Jobert S, Mejia-Constain B, Degroot C, Lafontaine AL, Lissemore JI, Smart K, Benkelfat C, Monchi O Abstract Using resting-state functional MRI (rsfMRI) data of younger and older healthy volunteers and patients with Parkinson's…
• Inflammation in Mild Cognitive Impairment due to Parkinson's disease, Lewy Body disease and Alzheimer's disease. April 18, 2019 Related ArticlesInflammation in Mild Cognitive Impairment due to Parkinson's disease, Lewy Body disease and Alzheimer's disease. Int J Geriatr Psychiatry. 2019 Apr 16;: Authors: King E, O'Brien J, Donaghy P, Williams-Gray CH, Lawson RA, Morris CM, Barnett N, Olsen K, Martin-Ruiz C, Burn D, Yarnall AJ, Taylor JP, Duncan G, Khoo TK, Thomas A Abstract BACKGROUND: Inflammation appears to play…
• Changes in Motor, Cognitive, and Behavioral Symptoms in Parkinson's Disease and Mild Cognitive Impairment During the COVID-19 Lockdown. January 1, 2021 Related ArticlesChanges in Motor, Cognitive, and Behavioral Symptoms in Parkinson's Disease and Mild Cognitive Impairment During the COVID-19 Lockdown. Front Psychiatry. 2020;11:590134 Authors: Baschi R, Luca A, Nicoletti A, Caccamo M, Cicero CE, D'Agate C, Di Giorgi L, La Bianca G, Lo Castro T, Zappia M, Monastero R Abstract Objective: The effects of the COVID-19 lockdown on subjects with prodromal…
• Conversion to MCI and dementia in Parkinson's disease: a systematic review and meta-analysis. May 22, 2019 Related ArticlesConversion to MCI and dementia in Parkinson's disease: a systematic review and meta-analysis. Parkinsonism Relat Disord. 2019 May 07;: Authors: Saredakis D, Collins-Praino LE, Gutteridge DS, Stephan BCM, Keage HAD Abstract OBJECTIVE: To systematically review and meta-analyse conversion rates from normal cognition to Mild Cognitive Impairment (MCI) and dementia in Parkinson's disease (PD) patients. Reversion rates in patients with…
• Memory-related Mild Cognitive Impairment May Be Linked to More Severe Alpha-Synuclein Buildup, Researchers Say February 13, 2020 Memory-related mild cognitive impairment in Parkinson’s disease may be associated with a more severe buildup of alpha-synuclein protein in the brain — such as that observed in more advanced stages of the disease, a study finds. The results of the study, “Neuropathological Findings in Parkinson’s Disease With Mild Cognitive Impairment,” were published in Movement Disorders. Studying neuropathological markers — meaning…
• Memory-related Mild Cognitive Impairment May Be Linked to More Severe Alpha-Synuclein Buildup, Researchers Say February 13, 2020 Memory-related mild cognitive impairment in Parkinson’s disease may be associated with a more severe buildup of alpha-synuclein protein in the brain — such as that observed in more advanced stages of the disease, a study finds. The results of the study, “Neuropathological Findings in Parkinson’s Disease With Mild Cognitive Impairment,” were published in Movement Disorders. Studying neuropathological markers — meaning…
• Monthly research review: February 2020 February 29, 2020   At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during February 2020. The post is divided into seven parts based on the type of research: Basic biology Disease mechanism Clinical research New clinical trials Clinical trial news Other news Review…
• EEG Plus Machine-learning Identifies Mild Cognitive Impairment, Study Finds December 9, 2020 Using non-invasive, dry-electroencephalography (EEG) and machine-learning computer algorithms, researchers were able to distinguish between Parkinson’s disease patients with and without mild cognitive impairments with 80% accuracy, early results of a study found.  Follow-up assessments will be conducted after 12 months to validate the method’s ability to predict cognitive impairment in this patient population.  The results were presented in a poster,…
• Neuroanatomical changes in early Parkinson's disease with mild cognitive impairment: a VBM study; the Parkinson's Disease Cognitive Impairment Study (PaCoS). January 16, 2021 Related ArticlesNeuroanatomical changes in early Parkinson's disease with mild cognitive impairment: a VBM study; the Parkinson's Disease Cognitive Impairment Study (PaCoS). Neurol Sci. 2021 Jan 14;: Authors: Donzuso G, Monastero R, Cicero CE, Luca A, Mostile G, Giuliano L, Baschi R, Caccamo M, Gagliardo C, Palmucci S, Zappia M, Nicoletti A Abstract INTRODUCTION: Mild cognitive impairment (MCI) is common in…
• Resting-state basal ganglia network codes a motor musical skill and its disruption From dystonia. September 13, 2019 Related ArticlesResting-state basal ganglia network codes a motor musical skill and its disruption From dystonia. Mov Disord. 2018 09;33(9):1472-1480 Authors: Kita K, Rokicki J, Furuya S, Sakamoto T, Hanakawa T Abstract BACKGROUND: Musician's dystonia critically impacts professional musicians' careers as they may lose musical skills, which have been acquired through long and intensive training. Yet the pathophysiology of musician's dystonia…
• Dynamic functional connectivity changes associated with dementia in Parkinson's disease. July 8, 2019 Related ArticlesDynamic functional connectivity changes associated with dementia in Parkinson's disease. Brain. 2019 Jul 06;: Authors: Fiorenzato E, Strafella AP, Kim J, Schifano R, Weis L, Antonini A, Biundo R Abstract Dynamic functional connectivity captures temporal variations of functional connectivity during MRI acquisition and it may be a suitable method to detect cognitive changes in Parkinson's disease. In this study,…
• Everyday Stepping Quantity and Quality Among Older Adult Fallers With and Without Mild Cognitive Impairment: Initial Evidence for New Motor Markers of Cognitive Deficits? September 4, 2019 Related ArticlesEveryday Stepping Quantity and Quality Among Older Adult Fallers With and Without Mild Cognitive Impairment: Initial Evidence for New Motor Markers of Cognitive Deficits? J Gerontol A Biol Sci Med Sci. 2018 07 09;73(8):1078-1082 Authors: Hausdorff JM, Hillel I, Shustak S, Del Din S, Bekkers EMJ, Pelosin E, Nieuwhof F, Rochester L, Mirelman A Abstract Background: Recent work demonstrated…
• Machine-learning identifies parkinson's disease patients based on resting-state between-network functional connectivity. April 18, 2019 Related ArticlesMachine-learning identifies parkinson's disease patients based on resting-state between-network functional connectivity. Br J Radiol. 2019 Apr 17;:20180886 Authors: Rubbert C, Mathys C, Jockwitz C, Hartmann CJ, Eickhoff SB, Hoffstaedter F, Caspers S, Eickhoff CR, Sigl B, Teichert NA, Südmeyer M, Turowski B, Schnitzler A, Caspers J Abstract OBJECTIVES: Evaluation of a data-driven, model-based classification approach to discriminate idiopathic Parkinson's…
• Phase lag index and spectral power as QEEG features for identification of patients with mild cognitive impairment in Parkinson's disease. August 25, 2019 Phase lag index and spectral power as QEEG features for identification of patients with mild cognitive impairment in Parkinson's disease. Clin Neurophysiol. 2019 Jul 25;130(10):1937-1944 Authors: Chaturvedi M, Bogaarts JG, Kozak Cozac VV, Hatz F, Gschwandtner U, Meyer A, Fuhr P, Roth V Abstract OBJECTIVES: To identify quantitative EEG frequency and connectivity features (Phase Lag Index) characteristic of mild cognitive…
• Analyses of Visuospatial and Visuoperceptual Errors as Predictors of Dementia in Parkinson's Disease Patients with Subjective Cognitive Decline and Mild Cognitive Impairment. December 12, 2020 Related ArticlesAnalyses of Visuospatial and Visuoperceptual Errors as Predictors of Dementia in Parkinson's Disease Patients with Subjective Cognitive Decline and Mild Cognitive Impairment. J Int Neuropsychol Soc. 2020 Dec 11;:1-11 Authors: Galtier I, Nieto A, Mata M, Lorenzo JN, Barroso J Abstract OBJECTIVE: Subjective cognitive decline (SCD) and mild cognitive impairment (MCI) in Parkinson's disease (PD) are considered as the…
• Nigrostriatal Dopaminergic Dysfunction and Altered Functional Connectivity in REM Sleep Behavior Disorder With Mild Motor Impairment. August 14, 2019 Related ArticlesNigrostriatal Dopaminergic Dysfunction and Altered Functional Connectivity in REM Sleep Behavior Disorder With Mild Motor Impairment. Front Neurol. 2019;10:802 Authors: Yamada G, Ueki Y, Oishi N, Oguri T, Fukui A, Nakayama M, Sano Y, Kandori A, Kan H, Arai N, Sakurai K, Wada I, Matsukawa N Abstract Rapid eye movement sleep behavior disorder is parasomnia characterized by symptoms of…
• Mild cognitive impairment reverters have a favorable cognitive prognosis and cortical integrity in Parkinson's disease. April 5, 2019 Related ArticlesMild cognitive impairment reverters have a favorable cognitive prognosis and cortical integrity in Parkinson's disease. Neurobiol Aging. 2019 Mar 11;78:168-177 Authors: Chung SJ, Park YH, Yoo HS, Lee YH, Ye BS, Sohn YH, Lee JM, Lee PH Abstract This study aimed to investigate whether reversion to cognitively normal status (CogN) is related to a favorable cognitive prognosis in Parkinson's…