An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of α-synuclein

An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of α-synuclein
Cell Rep. 2021 Jun 8;35(10):109189. doi: 10.1016/j.celrep.2021.109189.ABSTRACTNeuropathological and experimental evidence suggests that the cell-to-cell transfer of α-synuclein has an important role in the pathogenesis of Parkinson's disease (PD). However, the mechanism underlying this phenomenon is not fully understood. We undertook a small interfering RNA (siRNA), genome-wide screen to identify genes regulating the cell-to-cell transfer of α-synuclein. A genetically encoded reporter, ... read more
Source: PubMedPublished on 2021-06-09By Eleanna Kara