Belgian scientists identify ATP10B as novel risk gene for Parkinson’s disease

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• Scientists identify ATP10B as novel risk gene for Parkinson's disease April 10, 2020 Screening DNA of Parkinson's patients in the Christine Van Broeckhoven laboratory (VIB-UAntwerpen Center for Molecular Neurology) identified a new risk gene for Parkinson's disease. Mutations in ATP10B resulted in loss of ATP10B protein. The function of the ATP10B gene was revealed by the Peter Vangheluwe lab (KU Leuven, Laboratory of Cellular Transport Systems). They identified ATP10B as a transporter for…
• Scientists identify ATP10B as novel risk gene for Parkinson's disease April 10, 2020 Screening DNA of Parkinson's patients in the Christine Van Broeckhoven laboratory (VIB-UAntwerpen Center for Molecular Neurology) identified a new risk gene for Parkinson's disease. Mutations in ...
• Researchers identify new risk gene for Parkinson's disease April 12, 2020 Screening DNA of Parkinson's patients in the Christine Van Broeckhoven laboratory (VIB-UAntwerpen Center for Molecular Neurology) identified a new risk gene for Parkinson's disease. Mutations in ...
• Scientists identify novel risk gene for Parkinson's disease April 12, 2020 Belgian scientists have identified a novel risk gene for Parkinson's disease that can help find effective therapy against a disease that affects over 10 million people worldwide. Parkinson's ...
• Mutations in ATP10B Gene May Increase Risk of Parkinson’s, Study Finds April 15, 2020 Mutations in a gene called ATP10B may increase the risk of developing Parkinson’s disease, a study has found. When mutated, ATP10B is no longer able to provide instructions to make a functional protein that is necessary to transport a fatty substance — known to play a key role in Parkinson’s — out of lysosomes, the cell compartments responsible for digesting…
• Effects of glucocerebrosidase gene polymorphisms and mutations on the risk of Parkinson's disease dementia: a meta-analysis. November 2, 2019 Related ArticlesEffects of glucocerebrosidase gene polymorphisms and mutations on the risk of Parkinson's disease dementia: a meta-analysis. Neurosci Lett. 2019 Oct 28;:134544 Authors: Zhang Y, Chen J, Xu C, Feng J, Li J Abstract OBJECTIVE: Exploring the impact of glucocerebrosidase gene (GBA) polymorphisms and mutations on the pathogenesis of Parkinson's disease dementia (PDD) plays an important role in the diagnosis…
• Mutations on NUS1 Gene Can Significantly Raise Person’s Risk of Parkinson’s, Study Reports November 9, 2018 Mutations affecting the NUS1 gene are linked to a significantly increased risk — 11 times higher — of developing Parkinson’s disease, study shows. The study, “Coding mutations in NUS1 contribute to Parkinson’s disease,” was published in Proceedings of the National Academy of Sciences. Although exact triggers of Parkinson’s disease remain unclear, aging, and environmental and genetic factors are believed to be major culprits.…
• Mutation and association analyses of dementia-causal genes in Han Chinese patients with early-onset and familial Alzheimer's disease. April 8, 2019 Related ArticlesMutation and association analyses of dementia-causal genes in Han Chinese patients with early-onset and familial Alzheimer's disease. J Psychiatr Res. 2019 Mar 30;113:141-147 Authors: Wang G, Zhang DF, Jiang HY, Fan Y, Ma L, Shen Z, Bi R, Xu M, Tan L, Shan B, Yao YG, Feng T Abstract Alzheimer's disease (AD) is the most common cause of dementia…
• Keeping Pace of LRRK2 and GCase December 10, 2019 There are a number of genetic variations that can increase one's risk of developing Parkinson's. Two of the most common genetic variations or mutations occur in regions of human DNA known as the 'LRRK2' gene and the 'GBA' gene (a gene being a functional section of DNA). These mutations usually occur independent of each other, and they are very rare…
• Scientists identify novel risk gene for Parkinson’s disease April 11, 2020 Parkinson's patients display a variety of motor and non-motor symptoms, impeding their ability to perform basic everyday activities. With currently no effective therapy, the chronic and progressive ...
• Alpha-synuclein gene polymorphism affects risk of dementia in Han Chinese with Parkinson's disease. May 19, 2019 Alpha-synuclein gene polymorphism affects risk of dementia in Han Chinese with Parkinson's disease. Neurosci Lett. 2019 May 15;: Authors: Zheng J, Zang Q, Hu F, Wei H, Ma J, Xu Y Abstract BACKGROUND: Single-nucleotide polymorphisms (SNPs) in the SNCA gene encoding alpha-synuclein have been shown to affect the PD phenotype. However, whether such polymorphisms can influence risk of dementia in…
• A New Enzyme to Inhibit LRRK2 November 5, 2019 Researchers in Dundee (Scotland) and Stanford (USA) have identified a novel method of reducing LRRK2 activity in Parkinson's. Mutations in the gene that codes for the leucine-rich repeat kinase 2 or the LRRK2 gene are a major cause of familial and sporadic (non-familial) Parkinson's. LRRK2 is a complex protein, a part of which acts as an enzyme catalyst and interacts…
• Mutations of the bassoon gene causing new brain disorder March 23, 2018 Newly discovered gene mutations may help explain the cause of a disease that drastically impairs walking and thinking.
• Mutations of the bassoon gene causing new brain disorder March 23, 2018 Newly discovered gene mutations may help explain the cause of a disease that drastically impairs walking and thinking.
• Mutations of the bassoon gene causing new brain disorder March 23, 2018 Newly discovered gene mutations may help explain the cause of a disease that drastically impairs walking and thinking.
• Mutations of the bassoon gene causing new brain disorder March 23, 2018 Newly discovered gene mutations may help explain the cause of a disease that drastically impairs walking and thinking.
• Mutations of the bassoon gene causing new brain disorder March 23, 2018 Newly discovered gene mutations may help explain the cause of a disease that drastically impairs walking and thinking.
• Mutations of the bassoon gene causing new brain disorder March 23, 2018 Newly discovered gene mutations may help explain the cause of a disease that drastically impairs walking and thinking.
• Gene That Causes People To Be Left-Handed Identified - Medical Daily September 9, 2019 Gene That Causes People To Be Left-Handed Identified  Medical DailyA British study is the first to identify which genetic variants separate left-handed from right-handed people.
• Unravelling the mystery of how one gene contributes to Parkinson's, Crohn's and leprosy - EurekAlert September 25, 2019 Unravelling the mystery of how one gene contributes to Parkinson's, Crohn's and leprosy  EurekAlertResearchers have struggled for years to understand how mutations in one gene, called LRRK2, can increase the risk of three very different diseases: ...