Binding of Natural Inhibitors to Respiratory Complex I

Binding of Natural Inhibitors to Respiratory Complex I
Pharmaceuticals (Basel). 2022 Aug 31;15(9):1088. doi: 10.3390/ph15091088.ABSTRACTNADH:ubiquinone oxidoreductase (respiratory complex I) is a redox-driven proton pump with a central role in mitochondrial oxidative phosphorylation. The ubiquinone reduction site of complex I is located in the matrix arm of this large protein complex and connected to the membrane via a tunnel. A variety of chemically diverse compounds are known to inhibit ... read more
Source: PubMedPublished on 2022-09-23By Jonathan Schiller