Brain Insulin Resistance: Focus on Insulin Receptor-Mitochondria Interactions

Brain Insulin Resistance: Focus on Insulin Receptor-Mitochondria Interactions
Life (Basel). 2021 Mar 22;11(3):262. doi: 10.3390/life11030262.ABSTRACTCurrent hypotheses implicate insulin resistance of the brain as a pathogenic factor in the development of Alzheimer's disease and other dementias, Parkinson's disease, type 2 diabetes, obesity, major depression, and traumatic brain injury. A variety of genetic, developmental, and metabolic abnormalities that lead to disturbances in the insulin receptor signal transduction may underlie insulin ... read more
Source: PubMedPublished on 2021-04-03By Igor Pomytkin