Caffeine plus haloperidol reduces fatigue in an experimental model of Parkinson’s disease – a prospective to A2AR-D2R heterodimer antagonism

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• Caffeine plus haloperidol reduces fatigue in an experimental model of Parkinson's disease - a prospective to A2AR-D2R heterodimer antagonism March 15, 2023 Purinergic Signal. 2023 Mar 15. doi: 10.1007/s11302-023-09933-2. Online ahead of print.ABSTRACTFatigue is a non-motor symptom of Parkinson's disease (PD). Adenosine 2A receptor (A2AR) and compromised dopamine neurotransmission are linked to fatigue. Studies demonstrate that A2AR antagonism potentiates dopamine transmission via dopamine receptor D2 (D2R). However, the heterodimer form of A2AR-D2R in the striatum prompted questions about the therapeutic targets for…
• Caffeine plus haloperidol reduces fatigue in an experimental model of Parkinson's disease - a prospective to A2AR-D2R heterodimer antagonism March 15, 2023 Purinergic Signal. 2023 Mar 15. doi: 10.1007/s11302-023-09933-2. Online ahead of print.ABSTRACTFatigue is a non-motor symptom of Parkinson's disease (PD). Adenosine 2A receptor (A2AR) and compromised dopamine neurotransmission are linked to fatigue. Studies demonstrate that A2AR antagonism potentiates dopamine transmission via dopamine receptor D2 (D2R). However, the heterodimer form of A2AR-D2R in the striatum prompted questions about the therapeutic targets for…
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