Calabria as a Genetic Isolate: A Model for the Study of Neurodegenerative Diseases

Calabria as a Genetic Isolate: A Model for the Study of Neurodegenerative Diseases
Biomedicines. 2022 Sep 15;10(9):2288. doi: 10.3390/biomedicines10092288.ABSTRACTAlthough originally multi-ethnic in its structure, nowadays the Calabria region of southern Italy represents an area with low genetic heterogeneity and a high level of consanguinity that allows rare mutations to be maintained due to the founder effect. A complex research methodology-ranging from clinical activity to the genealogical reconstruction of families/populations across the centuries, the ... read more
Source: PubMedPublished on 2022-09-23By Francesco Bruno