Calmodulin Binding Domains in Critical Risk Proteins Involved in Neurodegeneration

Calmodulin Binding Domains in Critical Risk Proteins Involved in Neurodegeneration
Curr Issues Mol Biol. 2022 Nov 21;44(11):5802-5814. doi: 10.3390/cimb44110394.ABSTRACTNeurodegeneration leads to multiple early changes in cognitive, emotional, and social behaviours and ultimately progresses to dementia. The dysregulation of calcium is one of the earliest potentially initiating events in the development of neurodegenerative diseases. A primary neuronal target of calcium is the small sensor and effector protein calmodulin that, in response ... read more
Source: PubMedPublished on 2022-11-24By Danton H O'Day