Cerebral Dopamine Neurotrophic Factor Reduces α-Synuclein Aggregation and Propagation and Alleviates Behavioural Alterations in vivo

Cerebral Dopamine Neurotrophic Factor Reduces α-Synuclein Aggregation and Propagation and Alleviates Behavioural Alterations in vivo
Mol Ther. 2021 Apr 30:S1525-0016(21)00249-5. doi: 10.1016/j.ymthe.2021.04.035. Online ahead of print.ABSTRACTA molecular hallmark in Parkinson's Disease (PD) pathogenesis are α-synuclein aggregates. Cerebral dopamine neurotrophic factor (CDNF) is an atypical growth factor that is mostly resident in the endoplasmic reticulum but exerts its effects both intracellularly and extracellularly. One of the beneficial effects of CDNF can be protecting neurons from the ... read more
Source: PubMedPublished on 2021-05-03By Katrina Albert