Cerebrospinal fluid levels of proenkephalin and prodynorphin are differentially altered in Huntington’s and Parkinson’s disease

Cerebrospinal fluid levels of proenkephalin and prodynorphin are differentially altered in Huntington’s and Parkinson’s disease
J Neurol. 2022 Jun 23. doi: 10.1007/s00415-022-11187-8. Online ahead of print.ABSTRACTBACKGROUND: Proenkephalin (PENK) and prodynorphin (PDYN) are peptides mainly produced by the striatal medium spiny projection neurons (MSNs) under dopaminergic signaling. Therefore, they may represent candidate biomarkers in Huntington's disease (HD) and Parkinson's disease (PD), two neurodegenerative diseases characterized by striatal atrophy and/or dysfunction.METHODS: Using an in-house established liquid chromatography-tandem ... read more
Source: PubMedPublished on 2022-06-23By Peggy Barschke