Changes in prefrontal cortical activity and turning in response to dopaminergic and cholinergic therapy in Parkinson’s disease: A randomized cross-over trial

Changes in prefrontal cortical activity and turning in response to dopaminergic and cholinergic therapy in Parkinson’s disease: A randomized cross-over trial
Parkinsonism Relat Disord. 2021 Mar 27;86:10-14. doi: 10.1016/j.parkreldis.2021.03.014. Online ahead of print.ABSTRACTINTRODUCTION: Cholinergic dysfunction contributes to mobility deficits in Parkinson's disease (PD). People with PD rely on limited prefrontal executive-attentional resources for the control of locomotion, including turning. Cortical and behavioral responses to cholinergic augmentation during turning remains unclear. We examined prefrontal cortex (PFC) activity while turning-in-place and spatiotemporal measures ... read more
Source: PubMedPublished on 2021-04-04By Rodrigo Vitorio