Chelation Combination-A Strategy to Mitigate the Neurotoxicity of Manganese, Iron, and Copper?

Chelation Combination-A Strategy to Mitigate the Neurotoxicity of Manganese, Iron, and Copper?
Biomolecules. 2022 Nov 18;12(11):1713. doi: 10.3390/biom12111713.ABSTRACTThe chelating thiol dimercaptosuccinate (DMSA) and the traditional agent D-penicillamine (PSH) are effective in enhancing the urinary excretion of copper (Cu) and lead (Pb) in poisoned individuals. However, DMSA, PSH, EDTA (ethylenediamine tetraacetate), and deferoxamine (DFOA) are water-soluble agents with limited access to the central nervous system (CNS). Strategies for mobilization of metals such as ... read more
Source: PubMedPublished on 2022-11-24By Jan O Aaseth