Clinical and neuropathological diversity of tauopathy in MAPT duplication carriers

Clinical and neuropathological diversity of tauopathy in MAPT duplication carriers
Acta Neuropathol. 2021 Jun 6. doi: 10.1007/s00401-021-02320-4. Online ahead of print.ABSTRACTMicroduplications of the 17q21.31 chromosomal region encompassing the MAPT gene, which encodes the Tau protein, were identified in patients with a progressive disorder initially characterized by severe memory impairment with or without behavioral changes that can clinically mimic Alzheimer disease. The unique neuropathological report showed a primary tauopathy, which could ... read more
Source: PubMedPublished on 2021-06-07By David Wallon