Clinical, neuropathological and genetic features of Lewy body dementias.

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• Pathological Influences on Clinical Heterogeneity in Lewy Body Diseases. October 30, 2019 Pathological Influences on Clinical Heterogeneity in Lewy Body Diseases. Mov Disord. 2019 Oct 29;: Authors: Coughlin DG, Hurtig HI, Irwin DJ Abstract PD, PD with dementia, and dementia with Lewy bodies are clinical syndromes characterized by the neuropathological accumulation of alpha-synuclein in the CNS that represent a clinicopathological spectrum known as Lewy body disorders. These clinical entities have marked heterogeneity…
• Clinical and neuropathological differences between Parkinson's disease, Parkinson's disease dementia, and dementia with Lewy bodies - current issues and future directions. March 21, 2019 Related ArticlesClinical and neuropathological differences between Parkinson's disease, Parkinson's disease dementia, and dementia with Lewy bodies - current issues and future directions. J Neurochem. 2019 Mar 20;: Authors: Walker L, Stefanis L, Attems J Abstract Lewy body diseases (LBDs) share clinical, pathological, genetic, and biochemical signatures, and are regarded as a highly heterogeneous group of neurodegenerative disorders. Inclusive of Parkinson's…
• Cognitive fluctuations in Lewy body dementia: towards a pathophysiological framework. October 16, 2019 Cognitive fluctuations in Lewy body dementia: towards a pathophysiological framework. Brain. 2019 Oct 15;: Authors: Matar E, Shine JM, Halliday GM, Lewis SJG Abstract Fluctuating cognition is a complex and disabling symptom that is seen most frequently in the context of Lewy body dementias encompassing dementia with Lewy bodies and Parkinson's disease dementia. In fact, since their description over three…
• Fluctuating cognition in the Lewy body dementias. August 15, 2019 Related ArticlesFluctuating cognition in the Lewy body dementias. Brain. 2019 Aug 14;: Authors: O'Dowd S, Schumacher J, Burn DJ, Bonanni L, Onofrj M, Thomas A, Taylor JP Abstract Fluctuating cognition is a core diagnostic feature of dementia with Lewy bodies and is also a key clinical feature of Parkinson's disease dementia. These dementias share common pathological features and are referred…
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• New evidence on the management of Lewy body dementia - The Lancet September 10, 2019 New evidence on the management of Lewy body dementia  The LancetDementia with Lewy bodies and Parkinson's disease dementia, jointly known as Lewy body dementia, are common neurodegenerative conditions. Patients with ...
• Neuroimaging in Dementias. March 30, 2019 Related ArticlesNeuroimaging in Dementias. Semin Neurol. 2019 Apr;39(2):188-199 Authors: Mahalingam S, Chen MK Abstract Dementia is a global health issue, the burden of which will worsen with an increasingly aging population. Alzheimer's disease (AD) is the most common dementia, with 50 to 60% of all dementias attributable to AD alone, while the rest are mostly due to frontotemporal lobar dementia,…
• Neuropathology of dementia in patients with Parkinson's disease: a systematic review of autopsy studies. August 25, 2019 Related ArticlesNeuropathology of dementia in patients with Parkinson's disease: a systematic review of autopsy studies. J Neurol Neurosurg Psychiatry. 2019 Aug 23;: Authors: Smith C, Malek N, Grosset K, Cullen B, Gentleman S, Grosset DG Abstract BACKGROUND: Dementia is a common, debilitating feature of late Parkinson's disease (PD). PD dementia (PDD) is associated with α-synuclein propagation, but coexistent Alzheimer's disease…
• Cortical thinning in dementia with Lewy bodies and Parkinson disease dementia. November 8, 2019 Cortical thinning in dementia with Lewy bodies and Parkinson disease dementia. Aust N Z J Psychiatry. 2019 Nov 07;:4867419885165 Authors: Colloby SJ, Watson R, Blamire AM, O'Brien JT, Taylor JP Abstract BACKGROUND: We investigated the structural changes associated with Alzheimer's disease, dementia with Lewy bodies and Parkinson disease dementia by means of cortical thickness analysis. METHODS: Two hundred and forty-five…
• New evidence on the management of Lewy body dementia. September 15, 2019 Related ArticlesNew evidence on the management of Lewy body dementia. Lancet Neurol. 2019 Sep 10;: Authors: Taylor JP, McKeith IG, Burn DJ, Boeve BF, Weintraub D, Bamford C, Allan LM, Thomas AJ, O'Brien JT Abstract Dementia with Lewy bodies and Parkinson's disease dementia, jointly known as Lewy body dementia, are common neurodegenerative conditions. Patients with Lewy body dementia present with…
• Parkinson's Disease Dementia and Lewy Body Disease. March 30, 2019 Related ArticlesParkinson's Disease Dementia and Lewy Body Disease. Semin Neurol. 2019 Apr;39(2):274-282 Authors: Sezgin M, Bilgic B, Tinaz S, Emre M Abstract Dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PD-D) are Lewy body-related neurodegenerative disorders sharing common clinical and neuropathological findings. The clinical features of both conditions include cognitive impairment, behavioral symptoms, autonomic dysfunction, sleep disorders, and parkinsonism.…
• Small Vessel Disease Pathological Changes in Neurodegenerative and Vascular Dementias concomitant with Autonomic Dysfunction. July 30, 2019 Small Vessel Disease Pathological Changes in Neurodegenerative and Vascular Dementias concomitant with Autonomic Dysfunction. Brain Pathol. 2019 Jul 29;: Authors: Hase Y, Polvikoski TM, Firbank MJ, Craggs LJ, Hawthorne E, Platten C, Stevenson W, Deramecourt V, Ballard C, Kenny RA, Perry RH, Ince P, Carare RO, Allan LM, Horsburgh K, Kalaria RN Abstract We performed a clinicopathological study to assess…
• Dementia with Lewy bodies: Unique genetic profile identified December 17, 2017 Dementia with Lewy bodies has a unique genetic profile, distinct from those of Alzheimer's disease or Parkinson's disease, according to the first large-scale genetic study of this common type of dementia.
• Diagnosis and Management of Autonomic Dysfunction in Dementia Syndromes. July 11, 2019 Diagnosis and Management of Autonomic Dysfunction in Dementia Syndromes. Curr Treat Options Neurol. 2019 Jul 10;21(8):38 Authors: Allan LM Abstract PURPOSE OF REVIEW: Autonomic dysfunction is common in dementia, particularly in the Lewy body dementias. This review considers the evidence for autonomic dysfunction in dementia, common symptoms and potential management options. RECENT FINDINGS: Autonomic dysfunction has been shown in Alzheimer's…
• Dementia with lewy bodies: GBA1 mutations are associated with cerebrospinal fluid alpha-synuclein profile. June 13, 2019 Dementia with lewy bodies: GBA1 mutations are associated with cerebrospinal fluid alpha-synuclein profile. Mov Disord. 2019 Jun 12;: Authors: Lerche S, Machetanz G, Wurster I, Roeben B, Zimmermann M, Pilotto A, Preische O, Stransky E, Deuschle C, Hauser AK, Schulte C, Lachmann I, Waniek K, Gasser T, Berg D, Maetzler W, Brockmann K Abstract BACKGROUND: Patients with dementia with Lewy…
• Cholinergic deficits and galaninergic hyperinnervation of the nucleus basalis of Meynert in Alzheimer's disease and Lewy body disorders. August 28, 2019 Related ArticlesCholinergic deficits and galaninergic hyperinnervation of the nucleus basalis of Meynert in Alzheimer's disease and Lewy body disorders. Neuropathol Appl Neurobiol. 2019 Aug 27;: Authors: Alexandris AS, Walker L, Liu AKL, McAleese K, Johnson M, Pearce RKB, Gentleman SM, Attems J Abstract AIMS: Galanin is a highly inducible neuroprotective neuropeptide and in Alzheimer's disease (AD), a network of galaninergic…
• Consortia Assemble Worldwide to Take on Lewy Body Dementia - Alzforum July 20, 2019 Consortia Assemble Worldwide to Take on Lewy Body Dementia  AlzforumResearch into dementia with Lewy bodies has lagged behind that for Alzheimer's and Parkinson's diseases, in part because DLB is difficult to identify, and less ...
• Lewy Body Dementia Causes, Symptoms and Treatments - Being Patient April 9, 2019 Lewy Body Dementia Causes, Symptoms and Treatments  Being PatientLewy body dementia (LBD) accounts for nearly 20 percent of dementia cases worldwide. Discover what causes lewy body dementia, symptoms and treatments.
• Hippocampal CA2 Lewy pathology is associated with cholinergic degeneration in Parkinson's disease with cognitive decline. April 27, 2019 Related ArticlesHippocampal CA2 Lewy pathology is associated with cholinergic degeneration in Parkinson's disease with cognitive decline. Acta Neuropathol Commun. 2019 Apr 25;7(1):61 Authors: Liu AKL, Chau TW, Lim EJ, Ahmed I, Chang RC, Kalaitzakis ME, Graeber MB, Gentleman SM, Pearce RKB Abstract Although the precise neuropathological substrates of cognitive decline in Parkinson's disease (PD) remain elusive, it has long been…
• 5 things you should know about Lewy body dementia - Considerable September 20, 2019 5 things you should know about Lewy body dementia  ConsiderableIf someone asked you what causes dementia, you'll probably say Alzheimer's. But the second most common cause of dementia is still shrouded in mystery.