Cognitive deficits and altered cholinergic innervation in young adult male mice carrying a Parkinson’s disease Lrrk2G2019S knockin mutation

Cognitive deficits and altered cholinergic innervation in young adult male mice carrying a Parkinson’s disease Lrrk2G2019S knockin mutation
Exp Neurol. 2022 Jun 19:114145. doi: 10.1016/j.expneurol.2022.114145. Online ahead of print.ABSTRACTImpaired executive function is a common and debilitating non-motor symptom of idiopathic and hereditary Parkinson's disease (PD), but there is little understanding of the underlying pathophysiological mechanisms and circuits. The G2019S mutation in the kinase domain of leucine-rich repeat kinase 2 (LRRK2) greatly increases risk for late-onset PD, and non-manifesting ... read more
Source: PubMedPublished on 2022-06-22By Ayan Hussein