Combined Transcriptomic and Proteomic Analysis of Perk Toxicity Pathways

Combined Transcriptomic and Proteomic Analysis of Perk Toxicity Pathways
Int J Mol Sci. 2021 Apr 27;22(9):4598. doi: 10.3390/ijms22094598.ABSTRACTIn Drosophila, endoplasmic reticulum (ER) stress activates the protein kinase R-like endoplasmic reticulum kinase (dPerk). dPerk can also be activated by defective mitochondria in fly models of Parkinson's disease caused by mutations in pink1 or parkin. The Perk branch of the unfolded protein response (UPR) has emerged as a major toxic process ... read more
Source: PubMedPublished on 2021-04-30By Rebeka Popovic