Comparative Studies in the A30P and A53T alpha-Synuclein C. elegans Strains to Investigate the Molecular Origins of Parkinson’s Disease

Comparative Studies in the A30P and A53T alpha-Synuclein C. elegans Strains to Investigate the Molecular Origins of Parkinson’s Disease
Front Cell Dev Biol. 2021 Mar 22;9:552549. doi: 10.3389/fcell.2021.552549. eCollection 2021.ABSTRACTThe aggregation of α-synuclein is a hallmark of Parkinson's disease (PD) and a variety of related neurological disorders. A number of mutations in this protein, including A30P and A53T, are associated with familial forms of the disease. Patients carrying the A30P mutation typically exhibit a similar age of onset and ... read more
Source: PubMedPublished on 2021-04-08By Michele Perni