Could Amyloid-β 1-42 or α-Synuclein Interact Directly with Mitochondrial DNA? A Hypothesis

Could Amyloid-β 1-42 or α-Synuclein Interact Directly with Mitochondrial DNA? A Hypothesis
ACS Chem Neurosci. 2022 Sep 20. doi: 10.1021/acschemneuro.2c00512. Online ahead of print.ABSTRACTThe amyloid β (Aβ) and the α-synuclein (α-syn) are shown to be translocated into mitochondria. Even though their roles are widely investigated in pathological conditions, information on the presence and functions of Aβ and α-syn in mitochondria in endogenous levels is somewhat limited. We hypothesized that endogenous Aβ fragments ... read more
Source: PubMedPublished on 2022-09-20By Duygu Gezen-Ak