CR3 mediates rotenone-elicited degeneration of LC/NE neurons | JIR – Dove Medical Press

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• Microglial Activation Mediates Noradrenergic Locus Coeruleus Neurodegeneration via Complement Receptor 3 in a Rotenone-Induced Parkinson's Disease Mouse Model April 16, 2021 J Inflamm Res. 2021 Apr 9;14:1341-1356. doi: 10.2147/JIR.S299927. eCollection 2021.ABSTRACTBACKGROUND: Chronic exposure to the insecticide rotenone can damage dopaminergic neurons and lead to an increased risk of Parkinson's disease (PD). Whereas it is not clear whether rotenone induces neurodegeneration of noradrenergic locus coeruleus (LC/NE) neurons. Chronic neuroinflammation mediated by microglia has been involved in the pathogenesis of PD. Evidence shows…
• Microglial Activation Mediates Noradrenergic Locus Coeruleus Neurodegeneration via Complement Receptor 3 in a Rotenone-Induced Parkinson's Disease Mouse Model April 16, 2021 J Inflamm Res. 2021 Apr 9;14:1341-1356. doi: 10.2147/JIR.S299927. eCollection 2021.ABSTRACTBACKGROUND: Chronic exposure to the insecticide rotenone can damage dopaminergic neurons and lead to an increased risk of Parkinson's disease (PD). Whereas it is not clear whether rotenone induces neurodegeneration of noradrenergic locus coeruleus (LC/NE) neurons. Chronic neuroinflammation mediated by microglia has been involved in the pathogenesis of PD. Evidence shows…
• Microglial Activation Mediates Noradrenergic Locus Coeruleus Neurodegeneration via Complement Receptor 3 in a Rotenone-Induced Parkinson's Disease Mouse Model April 16, 2021 J Inflamm Res. 2021 Apr 9;14:1341-1356. doi: 10.2147/JIR.S299927. eCollection 2021.ABSTRACTBACKGROUND: Chronic exposure to the insecticide rotenone can damage dopaminergic neurons and lead to an increased risk of Parkinson's disease (PD). Whereas it is not clear whether rotenone induces neurodegeneration of noradrenergic locus coeruleus (LC/NE) neurons. Chronic neuroinflammation mediated by microglia has been involved in the pathogenesis of PD. Evidence shows…
• Microglial Activation Mediates Noradrenergic Locus Coeruleus Neurodegeneration via Complement Receptor 3 in a Rotenone-Induced Parkinson's Disease Mouse Model April 16, 2021 J Inflamm Res. 2021 Apr 9;14:1341-1356. doi: 10.2147/JIR.S299927. eCollection 2021.ABSTRACTBACKGROUND: Chronic exposure to the insecticide rotenone can damage dopaminergic neurons and lead to an increased risk of Parkinson's disease (PD). Whereas it is not clear whether rotenone induces neurodegeneration of noradrenergic locus coeruleus (LC/NE) neurons. Chronic neuroinflammation mediated by microglia has been involved in the pathogenesis of PD. Evidence shows…
• Microglial Activation Mediates Noradrenergic Locus Coeruleus Neurodegeneration via Complement Receptor 3 in a Rotenone-Induced Parkinson's Disease Mouse Model April 16, 2021 J Inflamm Res. 2021 Apr 9;14:1341-1356. doi: 10.2147/JIR.S299927. eCollection 2021.ABSTRACTBACKGROUND: Chronic exposure to the insecticide rotenone can damage dopaminergic neurons and lead to an increased risk of Parkinson's disease (PD). Whereas it is not clear whether rotenone induces neurodegeneration of noradrenergic locus coeruleus (LC/NE) neurons. Chronic neuroinflammation mediated by microglia has been involved in the pathogenesis of PD. Evidence shows…
• Microglial Activation Mediates Noradrenergic Locus Coeruleus Neurodegeneration via Complement Receptor 3 in a Rotenone-Induced Parkinson's Disease Mouse Model April 16, 2021 J Inflamm Res. 2021 Apr 9;14:1341-1356. doi: 10.2147/JIR.S299927. eCollection 2021.ABSTRACTBACKGROUND: Chronic exposure to the insecticide rotenone can damage dopaminergic neurons and lead to an increased risk of Parkinson's disease (PD). Whereas it is not clear whether rotenone induces neurodegeneration of noradrenergic locus coeruleus (LC/NE) neurons. Chronic neuroinflammation mediated by microglia has been involved in the pathogenesis of PD. Evidence shows…
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• Rifampicin attenuates rotenone-treated microglia inflammation via improving lysosomal function. October 25, 2019 Rifampicin attenuates rotenone-treated microglia inflammation via improving lysosomal function. Toxicol In Vitro. 2019 Oct 21;:104690 Authors: Liang Y, Zheng D, Peng S, Lin D, Jing X, Zeng Z, Chen Y, Huang K, Xie Y, Zhou T, Tao E Abstract Mounting evidence suggests that lysosome dysfunction promotes the progression of several neurodegenerative diseases via hampering autophagy flux. While regulation of autophagy…
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