Designer D-peptides targeting the N-terminal region of α-synuclein to prevent parkinsonian-associated fibrilization and cytotoxicity

Designer D-peptides targeting the N-terminal region of α-synuclein to prevent parkinsonian-associated fibrilization and cytotoxicity
Biochim Biophys Acta Proteins Proteom. 2022 Aug 1:140826. doi: 10.1016/j.bbapap.2022.140826. Online ahead of print.ABSTRACTThe deposition of α-synuclein (αS) aggregates in the gut and the brain is ever present in cases of Parkinson's disease. While the central non-amyloidogenic-component (NAC) region of αS plays a critical role in fibrilization, recent studies have identified a specific sequence from within the N-terminal region (NTR, ... read more
Source: PubMedPublished on 2022-08-04By John R Horsley