Development of Halogenated-Chalcones Bearing with Dimethoxy Phenyl Head as Monoamine Oxidase-B Inhibitors

Development of Halogenated-Chalcones Bearing with Dimethoxy Phenyl Head as Monoamine Oxidase-B Inhibitors
Pharmaceuticals (Basel). 2022 Sep 16;15(9):1152. doi: 10.3390/ph15091152.ABSTRACTTwo series of dimethoxy-halogenated chalcones (DM1-DM20) were synthesized and tested for their ability to inhibit monoamine oxidase (MAOs). Compound DM2 exhibited the most significant inhibition against MAO-B with an IC50 value of 0.067 µM, followed by compound DM18 (IC50 = 0.118 µM), with selectivity index (SI) values of 93.88 and >338.98, respectively. However, none ... read more
Source: PubMedPublished on 2022-09-23By Nisha Abdul Rehuman