Discovery of a tetracyclic indole alkaloid that postpones fibrillation of hen egg white lysozyme protein

Discovery of a tetracyclic indole alkaloid that postpones fibrillation of hen egg white lysozyme protein
Int J Biol Macromol. 2021 Jun 4:S0141-8130(21)01196-X. doi: 10.1016/j.ijbiomac.2021.05.212. Online ahead of print.ABSTRACTProtein aggregation, such as amyloid fibril formation, is molecular hallmark of many neurodegenerative disorders including Alzheimer's, Parkinson's, and Prion disease. Indole alkaloids are well-known as the compounds having the ability to inhibit protein fibrillation. In this study, we experimentally and computationally have investigated the anti-amyloid property of a ... read more
Source: PubMedPublished on 2021-06-07By Hossein Ashrafian