Domain-Independent Inhibition of CBP/p300 Attenuates α-Synuclein Aggregation

Domain-Independent Inhibition of CBP/p300 Attenuates α-Synuclein Aggregation
ACS Chem Neurosci. 2021 Jun 10. doi: 10.1021/acschemneuro.1c00215. Online ahead of print.ABSTRACTNeurodegenerative diseases are associated with failed proteostasis and accumulation of insoluble protein aggregates that compromise neuronal function and survival. In Parkinson's disease, a major pathological finding is Lewy bodies and neurites that are mainly composed of phosphorylated and aggregated α-synuclein and fragments of organelle membranes. Here, we analyzed a ... read more
Source: PubMedPublished on 2021-06-10By Irena Hlushchuk