Cell Rep. 2023 Mar 13;42(3):112231. doi: 10.1016/j.celrep.2023.112231. Online ahead of print.ABSTRACTAuxilin participates in the uncoating of clathrin-coated vesicles (CCVs), thereby facilitating synaptic vesicle (SV) regeneration at presynaptic sites. Auxilin (DNAJC6/PARK19) loss-of-function mutations cause early-onset Parkinson's disease (PD). Here, we utilized auxilin knockout (KO) mice to elucidate the mechanisms through which auxilin deficiency and clathrin-uncoating deficits lead to PD. Auxilin KO ... read more
Source: PubMedPublished on 2023-03-15By D J Vidyadhara
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