Dual Effects: Intrastriatal Injection of α-syn N103/tau N368 Preformed Fibrils Promotes Endogenous α-synuclein Aggregates in the Proximal Colon

Dual Effects: Intrastriatal Injection of α-syn N103/tau N368 Preformed Fibrils Promotes Endogenous α-synuclein Aggregates in the Proximal Colon
J Parkinsons Dis. 2022 Jul 25. doi: 10.3233/JPD-223294. Online ahead of print.ABSTRACTBACKGROUND: Pathological changes in the brain can affect the gastrointestinal tract, whereas there is less evidence regarding the brain-gut axis.OBJECTIVE: To identify whether cerebral endogenous phosphorylated α-synuclein induces gastrointestinal dysfunction via the brain-gut axis, mediated by the vagus nerve.METHODS: α-syn N103/tau N368 preformed fibrils were injected into the dorsal ... read more
Source: PubMedPublished on 2022-08-01By Jialing Wang