Early glycolytic reprogramming controls microglial inflammatory activation

Early glycolytic reprogramming controls microglial inflammatory activation
J Neuroinflammation. 2021 Jun 9;18(1):129. doi: 10.1186/s12974-021-02187-y.ABSTRACTBACKGROUND: Microglial activation-mediated neuroinflammation plays an important role in the progression of neurodegenerative diseases. Inflammatory activation of microglial cells is often accompanied by a metabolic switch from oxidative phosphorylation to aerobic glycolysis. However, the roles and molecular mechanisms of glycolysis in microglial activation and neuroinflammation are not yet fully understood.METHODS: The anti-inflammatory effects and ... read more
Source: PubMedPublished on 2021-06-10By Junjie Cheng