Early motor response to dopamine replacement therapy in Parkinson’s disease patients carrying GBA variants

Early motor response to dopamine replacement therapy in Parkinson’s disease patients carrying GBA variants
J Neurol Sci. 2022 Jul 25;440:120354. doi: 10.1016/j.jns.2022.120354. Online ahead of print.ABSTRACTBACKGROUND: Mutations in the glucocerebrosidase (GBA) gene represent the most common genetic risk factor for Parkinson's Disease (PD) and are associated with a more aggressive motor phenotype at late stages. However, the motor response at early stages of disease remains understudied.METHODS: Retrospective study of PD patients that underwent next-generation ... read more
Source: PubMedPublished on 2022-07-30By Malco Rossi