Editorial: Autophagy in diseases-From basic to clinic

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• The radiologist at a Parkinson’s conference October 24, 2022 # # # # In 2015, a woman with dementia was sitting in hospice care, wheelchair-bound and largely non-communicative. As part of a research project, she was given repeated computed tomography (CT) scans of her brain. The effect of this seemingly harmless treatment was rather astonishing, and it has led to more research exploring the effect of low dose ionizing…
• Editorial: Autophagy in diseases-From basic to clinic January 23, 2023 Front Physiol. 2023 Jan 4;13:1115511. doi: 10.3389/fphys.2022.1115511. eCollection 2022.NO ABSTRACTPMID:36685179 | PMC:PMC9856833 | DOI:10.3389/fphys.2022.1115511
• Parkinson’s and Autoimmunity January 26, 2023 “I am always doing that which I cannot do, in order that I may learn how to do it.” Pablo Picasso “We have more possibilities available in each moment than we realize.” Nhat Hanh Précis: This post exists because I received a note from a reader concerned about using a substance that potentially was an immune enhancer, coupled with the…
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• 500 April 22, 2021 # # # # I started writing about the research being conducted in Parkinson’s in 2014.  If I’m honest, it was simply an experiment. Having failed to write the next great kiwi novel (think Katherine Mansfield, Margaret Mahy, Witi Ihimaera, Eleanor Catton, and most recently Rose Carlyle), to distract myself I started playing around with science writing to see if…
• Monitoring Autophagy in Neural Stem and Progenitor Cells July 1, 2022 Methods Mol Biol. 2022;2515:99-116. doi: 10.1007/978-1-0716-2409-8_7.ABSTRACTAutophagy is a critical cellular program that is necessary for cellular survival and adaptation to nutrient and metabolic stress. In addition to homeostatic maintenance and adaptive response functions, autophagy also plays an active role during development and tissue regeneration. Within the neural system, autophagy is important for stem cell maintenance and the ability of neural…
• Monitoring Autophagy in Neural Stem and Progenitor Cells July 1, 2022 Methods Mol Biol. 2022;2515:99-116. doi: 10.1007/978-1-0716-2409-8_7.ABSTRACTAutophagy is a critical cellular program that is necessary for cellular survival and adaptation to nutrient and metabolic stress. In addition to homeostatic maintenance and adaptive response functions, autophagy also plays an active role during development and tissue regeneration. Within the neural system, autophagy is important for stem cell maintenance and the ability of neural…
• Monitoring Autophagy in Neural Stem and Progenitor Cells July 1, 2022 Methods Mol Biol. 2022;2515:99-116. doi: 10.1007/978-1-0716-2409-8_7.ABSTRACTAutophagy is a critical cellular program that is necessary for cellular survival and adaptation to nutrient and metabolic stress. In addition to homeostatic maintenance and adaptive response functions, autophagy also plays an active role during development and tissue regeneration. Within the neural system, autophagy is important for stem cell maintenance and the ability of neural…
• Monitoring Autophagy in Neural Stem and Progenitor Cells July 1, 2022 Methods Mol Biol. 2022;2515:99-116. doi: 10.1007/978-1-0716-2409-8_7.ABSTRACTAutophagy is a critical cellular program that is necessary for cellular survival and adaptation to nutrient and metabolic stress. In addition to homeostatic maintenance and adaptive response functions, autophagy also plays an active role during development and tissue regeneration. Within the neural system, autophagy is important for stem cell maintenance and the ability of neural…
• Monitoring Autophagy in Neural Stem and Progenitor Cells July 1, 2022 Methods Mol Biol. 2022;2515:99-116. doi: 10.1007/978-1-0716-2409-8_7.ABSTRACTAutophagy is a critical cellular program that is necessary for cellular survival and adaptation to nutrient and metabolic stress. In addition to homeostatic maintenance and adaptive response functions, autophagy also plays an active role during development and tissue regeneration. Within the neural system, autophagy is important for stem cell maintenance and the ability of neural…
• Monitoring Autophagy in Neural Stem and Progenitor Cells July 1, 2022 Methods Mol Biol. 2022;2515:99-116. doi: 10.1007/978-1-0716-2409-8_7.ABSTRACTAutophagy is a critical cellular program that is necessary for cellular survival and adaptation to nutrient and metabolic stress. In addition to homeostatic maintenance and adaptive response functions, autophagy also plays an active role during development and tissue regeneration. Within the neural system, autophagy is important for stem cell maintenance and the ability of neural…
• Monitoring Autophagy in Neural Stem and Progenitor Cells July 1, 2022 Methods Mol Biol. 2022;2515:99-116. doi: 10.1007/978-1-0716-2409-8_7.ABSTRACTAutophagy is a critical cellular program that is necessary for cellular survival and adaptation to nutrient and metabolic stress. In addition to homeostatic maintenance and adaptive response functions, autophagy also plays an active role during development and tissue regeneration. Within the neural system, autophagy is important for stem cell maintenance and the ability of neural…
• Monitoring Autophagy in Neural Stem and Progenitor Cells July 1, 2022 Methods Mol Biol. 2022;2515:99-116. doi: 10.1007/978-1-0716-2409-8_7.ABSTRACTAutophagy is a critical cellular program that is necessary for cellular survival and adaptation to nutrient and metabolic stress. In addition to homeostatic maintenance and adaptive response functions, autophagy also plays an active role during development and tissue regeneration. Within the neural system, autophagy is important for stem cell maintenance and the ability of neural…
• Trying to LIMP-2 the lysosome February 8, 2021 # # # # Lysosomes are small bags of enzymes that are used to break down material inside of cells – digesting newly absorbed food or recycling old/used proteins and rubbish. Recently researchers have been discovering increasing evidence that points towards dysfunction in lysosomes as a key influential player in neurodegenerative conditions, like Parkinson’s. There are several Parkinson’s genetic risk…
• Methods to Study Mitochondria: Techniques Used to Study the Effects of Age-Related Diseases Including Alzheimer's January 17, 2023 Curr Protoc. 2023 Jan;3(1):e631. doi: 10.1002/cpz1.631.ABSTRACTVarious laboratories across the world have developed methods to study mitochondrial proteins/markers through extraction of mitochondrial RNA and protein to assess mitophagy/autophagy in Alzheimer's disease and other age-related diseases. Techniques outlined in this article include qRT-PCR, immunoblotting, immunofluorescence, transmission electron microscopy, Seahorse bioanalysis, staining for mitochondrial membrane potential, detection of mitophagy, and mitochondrial functional assays.…