Endogenous PTEN-Induced Kinase 1 Regulates Dendritic Architecture and Spinogenesis

Endogenous PTEN-Induced Kinase 1 Regulates Dendritic Architecture and Spinogenesis
J Neurosci. 2022 Oct 12;42(41):7848-7860. doi: 10.1523/JNEUROSCI.0785-22.2022. Epub 2022 Sep 7.ABSTRACTMutations in PTEN-induced kinase 1 (PINK1) contribute to autosomal recessive Parkinson's disease with cognitive and neuropsychiatric comorbidities. Disturbances in dendritic and spine architecture are hallmarks of neurodegenerative and neuropsychiatric conditions, but little is known of the impact of PINK1 on these structures. We used Pink1 -/- mice to study the ... read more
Source: PubMedPublished on 2022-11-22By P Anthony Otero