Evaluation of Ectopic Mitochondrial DNA in HeLa Cells

Evaluation of Ectopic Mitochondrial DNA in HeLa Cells
Curr Issues Mol Biol. 2022 Mar 2;44(3):1215-1223. doi: 10.3390/cimb44030080.ABSTRACTThe presence of ectopic DNA in the cytoplasm induces inflammation and cell death. It has been widely reported that leakage of nuclear DNA into the cytoplasm can mainly be sensed by cyclic GMP-AMP synthase (cGAS). We recently reported that mitochondria-derived cytoplasmic double-stranded DNA (dsDNA) that has escaped lysosomal degradation induces significant cytotoxicity ... read more
Source: PubMedPublished on 2022-06-20By Mohammad T Hussan