First patient included in AlzeCure’s Phase II clinical trial in neuropathic pain with non-opioid ACD440 – Marketscreener.com

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• The road ahead: 2022 January 20, 2022 # # # # The first post at the start of each year on the SoPD website tries to provide an overview of where things are in the search for ‘disease modifying’ therapies for Parkinson’s.  It is an exercise in managing expectations as well as discussing what research events are scheduled for the next year so that we can keep…
• The road ahead: 2021 January 25, 2021 # # # # At the start of each year, it is a useful practise to layout what is planned over the next 12 months. The events that are scheduled for the year to come, so that we can keep an eye out for them. Obviously, where 2021 will end actually is unpredictable, but an outline of what is scheduled…
• The road ahead: 2020 January 5, 2020 Here at the SoPD, we are primarily interested in disease modification for Parkinson’s. While there is a great deal of interesting research exploring the causes of the condition, novel symptomatic therapies, and other aspects of Parkinson’s, my focus is generally on the science seeking to slow, stop or reverse the condition. At the start of each year, it is a…
• ACTTION Partnership Publishes New Acute Neuropathic Pain Diagnostic Criteria March 17, 2021 Patients presenting with acute neuropathic pain represent a significant diagnostic challenge. As such, diagnostic criteria should reflect the mechanistic understanding of this pain as well as provide a framework for research and treatment of complex acute neuropathic pain conditions. Through a partnership of the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks (ACTTION), the US Food and…
• A Primer on Pain and Parkinson’s September 21, 2020 Introduction Studies show that between 60 and 83% of people with Parkinson’s report experiencing pain, and chronic pain is twice as common in people living with Parkinson’s than it is in those without Parkinson’s. Several different types of pain are associated with Parkinson’s, and effective management requires coordination with your care team and implementation of pharma- and non-pharmacological treatments. In…
• Study plan of AlzeCure's Phase II clinical study in neuropathic pain with non-opioid ACD440 now available - Marketscreener.com June 15, 2022 Study plan of AlzeCure's Phase II clinical study in neuropathic pain with non-opioid ACD440 now available  Marketscreener.com
• Is Pain a Symptom of Parkinson’s Disease? August 27, 2019 Pain is a common but overlooked problem in Parkinson’s disease. Pain is an often overlooked non-motor symptom of Parkinson’s disease (PD). Studies show that between 40-80% of people with PD report pain, which is likely why it is often suggested as a topic for this blog. (Please feel free to suggest a topic for future blog posts.) One of the…
• Parkinson Disease: The Breakdown and Pathophysiology of Chronic Pain February 16, 2021 Among the numerous non-motor symptoms affecting patients with Parkinson’s disease (PD), chronic pain has become a topic of increasing focus in recent years. In studies investigating the prevalence of pain in PD, figures have ranged from 30%-85% due to between-study differences in factors such as diagnostic criteria, sample sizes, and assessment methods used.1In a study that examined analgesic prescriptions as…
• Lower back pain and Parkinson’s disease August 24, 2021 Lower back pain and Parkinson’s disease Lower back pain is an extremely common problem in the general population, as well as for people with Parkinson’s disease (PD). It tends to make moving more difficult, adding to the challenges of PD. Tim Nordahl, PT, DPT, a physical therapist at Boston University gave an excellent presentation as part of APDA’s Let’s Keep…
• EJS-ACT PD June 26, 2021 # # # # This week an announcement was made regarding The Edmond J. Safra Accelerating Clinical Treatments for Parkinson’s Disease (EJS-ACT PD) Initiative. It is hoping to revolutionise the way clinical trials for potentially disease-modifying drugs for Parkinson’s are conducted. The project is focused on the setting up a multi-arm, multi-stage (MAMS) platform for evaluating new therapies for PD.…
• PAIN: Does Parkinson's Cause Pain, or Does Pain Make Other PD Symptoms Worse? July 17, 2019 Is pain a symptom of Parkinson’s? Or do the motor symptoms of PD directly or indirectly cause pain? Or is pain a symptom of something else? Arthritis? Aging? Or is pain a result of lack of exercise? Over exercise? Improper exercise form? Improper exercise instruction? Some combination of factors? Those are interesting questions, but more importantly does pain contribute to…
• First Patient Included in AlzeCure's Phase II Clinical Trial in Neuropathic Pain with Non-opioid ACD440 - GuruFocus.com June 21, 2022 First Patient Included in AlzeCure's Phase II Clinical Trial in Neuropathic Pain with Non-opioid ACD440  GuruFocus.com
• Deep Brain Stimulation: The Answer to Chronic Pain? January 15, 2021 Chronic pain affects 1 in every 4 adults in the United States, many of whom are resistant to pharmacotherapy.1 It is a significant burden to both individuals and healthcare systems, affecting mental health, cognitive function, and promoting opioid dependency.2 However, researchers are hot on the heels of discovering new ways to treat the condition — including via deep brain stimulation…
• AlzeCure gets Approval to Start Phase II Clinical Trial with Non-opioid Pain Project ACD440 - BioSpace May 25, 2022 AlzeCure gets Approval to Start Phase II Clinical Trial with Non-opioid Pain Project ACD440  BioSpace
• The PD-PCS: A New Approach to Classifying Pain in Patients With Parkinson Disease May 5, 2021 The Parkinson Disease-Pain Classification System (PD-PCS) is a valid, reliable tool to differentiate Parkinson disease-related pain from unrelated pain, with moderate inter- and intrarater reliability. This is according to research results published in Pain. Researchers conducted an international, cross-sectional, multicenter study with a retest validation step to test a new mechanism-based classification system to differentiate Parkinson disease-related pain from unrelated…
• Parkinson’s Medications Relieve Central Pain Better than Other Types of Pain, Study Finds May 17, 2019 Treatment with standard Parkinson’s therapies, such as levodopa or dopamine agonists, can provide effective relief of central parkinsonian pain, but they may fail to manage motor symptoms in these patients, a study has found. As many patients with Parkinson’s disease experience some type of pain, these findings suggest that clinicians should take an integrated approach to ensure adequate care for…
• The drug development pipeline for Parkinson’s December 2, 2020 # # # # For a long time a regular request from SoPD readers has been to provide an overview of the clinical trial landscape for Parkinson’s, particularly in the area of drug development. Such projects are difficult, however, as the landscape is broad and dynamic – lots of different approaches being applied and new entrants continually entering the arena.…
• 2020: Year in Review January 1, 2021 # # # # In this end-of-year post, we review the Parkinson’s research that caught our attention at SoPD HQ in 2020. Month-by-month we will briefly discuss some of the major pieces of research/ announcements that have defined the year and advanced our understanding of Parkinson’s. The list is based on nothing more than the author’s personal opinion – apologies…
• Managing Chronic Pain in Parkinson’s Disease February 17, 2019 “Behind every beautiful thing, there’s some kind of pain.” Bob Dylan “You feel your strength in the experience of pain.” Jim Morrison An Aging Population with Chronic Pain: The definition of chronic pain is pain that continues beyond the expected time of healing. Chronic pain can increase frailty, and it’s linked to falls, sleep disruption, depression, anxiety, and reduced physical…
• Monthly Research Review: January 2022 January 31, 2022 # # # # At the end of each month the SoPD writes a post which provides an overview of some of the major pieces of Parkinson’s-related research that were made available during January 2022. The post is divided into 10 parts based on the type of research: Top 6 pieces of Parkinson’s news Articles of general interest Basic biology…
• Sideways Viewing: A New Approach to Pain Management March 18, 2022 I lost most of my vision two years ago and became legally blind. It was devastating. Through the course of rehabilitation with a low vision clinic, I was taught how to see in a very new way, called eccentric viewing. Eccentric viewing is a method by which a person looks sideways at an object to see “around” the blinding scar…
• Such a Pain in the…Back? March 10, 2022 Do you have aches and pains? You are not alone. Muscle and joint pains are common as we age. Pain is a normal, protective sensation to help you prevent further serious injury to your body. For example, the pain one might get from burning their hand on a stove tells them to: 1) pull their hand off the stove and…