‘Focused’ ultrasound may help treat Parkinson’s disease – The Siasat Daily

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• MRI-Focused Ultrasound Undergoing Phase 3 Clinical Trial for Parkinson’s Treatment March 2, 2018 New technology that uses MRI-guided focused ultrasound to target areas of the brain affected by Parkinson’s disease and improve motor symptoms will be further tested in a pivotal Phase 3 clinical trial. Led by the University of Maryland Medical Center (UMMC) and the University of Maryland School of Medicine (UMSOM), the randomized trial will assess the safety and effectiveness of…
• Phase 3 Study of Exablate Neuro Ultrasound System to Treat Parkinson’s Motor Symptoms Begins May 1, 2018 The first patient with advanced Parkinson’s has been treated in a pivotal Phase 3 trial using MRI-guided focused ultrasound to address major motor symptoms of the disease. The multisite, randomized, and double-blinded clinical trial (NCT03319485) is evaluating the safety and effectiveness of MRI-guided focused ultrasound delivered to affected brain areas using Insightec’s Exablate Neuro system. It plans to enroll more than 100 patients…
• Ultrasound Approach Eases Dopaminergic Brain Damage in Mouse Model of Parkinson’s June 12, 2019 Using ultrasound coupled with the intravenous injection of microbubbles lessened brain damage in a mouse model of early Parkinson’s and may provide a noninvasive way to successfully deliver therapies into the brains of people with the disease, a study reports. A clinical trial with Alzheimer’s disease patients has been approved by the U.S. Food and Drug and Administration to test the safety…
• The role of high-intensity focused ultrasound as a symptomatic treatment for Parkinson's disease. July 11, 2019 The role of high-intensity focused ultrasound as a symptomatic treatment for Parkinson's disease. Mov Disord. 2019 Jul 10;: Authors: Moosa S, Martínez-Fernández R, Elias WJ, Del Alamo M, Eisenberg HM, Fishman PS Abstract MR-guided focused ultrasound is a novel, minimally invasive surgical procedure for symptomatic treatment of PD. With this technology, the ventral intermediate nucleus, STN, and internal globus pallidus…
• Ultrasound Can Reduce Tremors in Severe Cases of Parkinson’s, Study Suggests November 15, 2017 Ultrasound therapy can reduce the tremors of Parkinson’s patients who fail to respond to medication, a small clinical trial suggests. While the results were encouraging, larger studies are needed to confirm the technique’s effectiveness, researchers at the University of Virginia School of Medicine said. The study raises the possibility that severe tremors can be treated without brain surgery, since the ultrasound…
• Focused-ultrasound Lesion Surgery Can Treat Tremors and Improve Life Quality, Study Says December 5, 2018 Treating tremor in Parkinson’s patients using non-invasive and focused-ultrasound lesion surgery is associated with better quality of life when compared to deep brain stimulation, although both approaches are equally effective in easing this disease symptom, a review study reports. The study, “Outcomes in Lesion Surgery versus Deep Brain Stimulation in Patients with Tremor: A Systematic Review and Meta-analysis,” was published in the journal World Neurosurgery.…
• First Parkinson’s Patient Treated with Insightec’s Incisionless Brain Therapy May 11, 2018 Insightec has treated the first patient in a pivotal study of its non-invasive ultrasound therapy, ExAblate Neuro, for patients with advanced Parkinson’s who have not responded to medication. The device uses focused ultrasound and magnetic resonance imaging (MRI) to destroy a target deep in the brain — the Vim nucleus of the thalamus — through an intact skull. This area has been…
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• Ultrasound-activated Neurons Used to Study Parkinson’s, Other Neurodegenerative Diseases March 18, 2020 Using an engineered sound-sensitive protein, researchers have developed neurons that can be activated by ultrasound. This could be useful in studying, and even developing therapies for, neurological diseases, including Parkinson’s. The study, “Sonogenetic Modulation of Cellular Activities Using an Engineered Auditory-Sensing Protein,” was published in Nano Letters. The ability to control neuronal activity in a non-invasive manner is useful for basic…
• Daily Inspiration (Mantra) from the 2018 PWR! (Parkinson Wellness Recovery) Retreat June 7, 2018 “One of the hardest things in life is having words in your heart that you can’t utter.” James Earl Jones “Good actions are a guard against the blows of adversity.” Abu Bakr Introduction:  A new part of the recently completed PWR! (Parkinson Wellness Recovery) retreat for 2018 in Scottsdale, AZ was something termed “Daily Inspiration or Daily Mantra”.  At the…
• Daily Inspiration (Mantra) from the 2018 PWR! (Parkinson Wellness Recovery) Retreat June 7, 2018 “One of the hardest things in life is having words in your heart that you can’t utter.” James Earl Jones “Good actions are a guard against the blows of adversity.” Abu Bakr Introduction:  A new part of the recently completed PWR! (Parkinson Wellness Recovery) retreat for 2018 in Scottsdale, AZ was something termed “Daily Inspiration or Daily Mantra”.  At the…
• Daily Inspiration (Mantra) from the 2018 PWR! (Parkinson Wellness Recovery) Retreat June 7, 2018 “One of the hardest things in life is having words in your heart that you can’t utter.” James Earl Jones “Good actions are a guard against the blows of adversity.” Abu Bakr Introduction:  A new part of the recently completed PWR! (Parkinson Wellness Recovery) retreat for 2018 in Scottsdale, AZ was something termed “Daily Inspiration or Daily Mantra”.  At the…
• Parkinsonism Treatments August 26, 2019 Parkinsonism Treatments PARKINSONISM TREATMENTS Generic Brand Form Strength Adult Dose ANTICHOLINERGICS benztropine — scored tabs 0.5mg, 1mg, 2mg Initially 0.5−1mg at bedtime. May increase by 0.5mg at 5−6 day intervals; max 6mg daily. Cogentin amps 1mg/mL hyoscy–amine sulfate NuLev chew–able melt tabs 0.125mg 1−2 tabs every 4hrs or as needed; max 12 tabs/day trihexy–phenidyl — scored tabs 2mg, 5mg Give in 3−4…
• A “world-first” trial for Parkinson’s disease November 5, 2020 In a groundbreaking new clinical trial, scientists are using ultrasound technology to deliver therapy to specific brain regions affected by Parkinson’s disease Researchers in Canada are using focused ultrasound technology to deliver a Parkinson’s treatment directly to areas of the brain that are affected by the condition. With focused ultrasound, researchers can reach deep regions of the brain without cutting…
• Focused ultrasound in Parkinson's disease: A twofold path toward disease modification. August 15, 2019 Focused ultrasound in Parkinson's disease: A twofold path toward disease modification. Mov Disord. 2019 Aug 14;: Authors: Foffani G, Trigo-Damas I, Pineda-Pardo JA, Blesa J, Rodríguez-Rojas R, Martínez-Fernández R, Obeso JA Abstract A major unmet need in Parkinson's disease (PD) is to slow the inexorable progression of neurodegeneration. Clinical trials that evaluated promising pharmacological strategies have repeatedly failed. Nonetheless, the…
• Focused ultrasound opening of the blood-brain barrier for treatment of Parkinson's disease. May 29, 2019 Focused ultrasound opening of the blood-brain barrier for treatment of Parkinson's disease. Mov Disord. 2019 May 28;: Authors: LeWitt PA, Lipsman N, Kordower JH Abstract The expanding landscape of options for Parkinson's disease (PD) therapeutics calls for novel ways to improve delivery of treatments to counteract neurodegeneration or enhance symptomatic control. This unmet need is particularly relevant for opportunities in…
• Psychosis Treatments October 28, 2019 Psychosis Treatments PSYCHOSIS TREATMENTS Generic Brand Form Indication Adult Initial Dose Adult Dose Titration First-Generation Antipsychotics chlorpromazine HCl — tabs Psychosis. Mania Less acutely disturbed: 25mg three times dailyOutpatient: 10mg 3–4 times daily or 25mg 2–3 times dailySevere cases: 25mg three times daily Inpatient: 500–1000mg/dayLess acutely disturbed: 400mg/dayOutpatient: 200–800mg/day Increase dose gradually until symptoms are controlled. Continue optimum dosage for…
• Top 10 Parkinson’s Stories of 2018 January 2, 2019 Parkinson’s News Today provided you with daily coverage of important findings, treatment developments, and clinical trials related to Parkinson’s during 2018. We look forward to bringing more news to Parkinson’s patients, as well as their family members and caregivers, during 2019. Here are the Top 10 most-read articles of 2018, with a brief description of what made them interesting to the Parkinson’s community.  No.…
• Parkinson's Disease News - Editor's Picks (Archive 2016.11) March 17, 2017 Newsfeed: PD News PD Research News PD Fitness News PD Boxing News PD Web Articles PD Blogs PD Editor's Picks PD Twitter Newsfeed Neurons Paralyze Us During REM SleepIt will also be most useful in the study of Parkinson’s disease, since these pathologies are related. This work was published on December 12, 2016 on the website of the journal Brain.…
• Insightec Gets FDA Blessing for Study of Exablate Neuro to Treat Parkinson’s Involuntary Movements November 1, 2017 The U.S. Food and Drug Administration (FDA) has granted approval to Insightec to start a pivotal study of its Exablate Neuro technology. The ultrasound therapy aims to treat advanced Parkinson’s disease patients with involuntary muscle movements and motor fluctuations who don’t respond to medication. The principal investigator is Dr. Howard Eisenberg, a neurosurgery professor at the University of Maryland School of Medicine.…