Friend or Foe: Xenobiotic Activation of Nrf2 in Disease Control and Cardioprotection

Friend or Foe: Xenobiotic Activation of Nrf2 in Disease Control and Cardioprotection
Pharm Res. 2021 Feb 22. doi: 10.1007/s11095-021-02997-y. Online ahead of print.ABSTRACTNuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that governs a highly conserved pathway central to the protection of cells against various oxidative stresses. However, the biological impact of xenobiotic intervention of Nrf2 in physiological and pathophysiological conditions remains debatable. Activation of Nrf2 in cancer cells has ... read more
Source: PubMedPublished on 2021-02-23By William D Hedrich