Fyn knockdown prevents levodopa-induced dyskinesia in a mouse model of Parkinson’s disease

Fyn knockdown prevents levodopa-induced dyskinesia in a mouse model of Parkinson’s disease
eNeuro. 2021 Jun 7:ENEURO.0559-20.2021. doi: 10.1523/ENEURO.0559-20.2021. Online ahead of print.ABSTRACTDopamine replacement by levodopa is the most widely used therapy for Parkinson's disease (PD), however patients often develop side effects, known as levodopa-induced dyskinesia (LID), that usually need therapeutic intervention. There are no suitable therapeutic options for LID, except for the use of the NMDA receptor antagonist amantadine, which has limited ... read more
Source: PubMedPublished on 2021-06-08By Melina P Bordone