GDNF and Cell Transplantation: Dual therapies for Parkinson’s

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• GDNF and Cell Transplantation: Dual therapies for Parkinson's February 24, 2020 Parkinson's is a complex condition and it is becoming increasingly clear that the future of disease-modifying therapies for Parkinson's will rely on the use of multiple treatment approaches, as opposed to a single therapy. Scientists in Australia have recently published pre-clinical research exploring this idea - and assessing the effects of treating models of Parkinson's with a combination of different…
• Stem Cell (Dopamine Cell Replacement) Therapies For Parkinson's July 24, 2019 YouTube Video https://www.youtube.com/watch?v=fOa21v8MpGw Stem Cell Therapies for Parkinson's Although the underlying cause of Parkinson's is unknown, scientists do know that Parkinson's results from the impairment and loss of dopamine producing cells in an area of the brain called the substantia nigra. It stands to reason therefore that replacement of those cells is a viable and potentially potent treatment method. Although…
• Dopamine Replacement Cell Therapies - Research Updates April 1, 2019 Stem Cell Therapies for Parkinson's Although the underlying cause of Parkinson's is unknown, scientists do know that Parkinson's results from the impairment and loss of dopamine producing cells in an area of the brain called the substantia nigra. It stands to reason therefore that replacement of those cells is a viable and potentially potent treatment method. Although it is acknowledged…
• Dopamine Cell Replacement Therapies - Research Updates May 15, 2019 YouTube Video https://www.youtube.com/watch?v=fOa21v8MpGw Stem Cell Therapies for Parkinson's Although the underlying cause of Parkinson's is unknown, scientists do know that Parkinson's results from the impairment and loss of dopamine producing cells in an area of the brain called the substantia nigra. It stands to reason therefore that replacement of those cells is a viable and potentially potent treatment method. Although…
• Dopamine Cell Replacement Therapies - Research Updates May 9, 2019 YouTube Video https://www.youtube.com/watch?v=fOa21v8MpGw Stem Cell Therapies for Parkinson's Although the underlying cause of Parkinson's is unknown, scientists do know that Parkinson's results from the impairment and loss of dopamine producing cells in an area of the brain called the substantia nigra. It stands to reason therefore that replacement of those cells is a viable and potentially potent treatment method. Although…
• Are Stem Cell-Based Therapies for Parkinson’s Disease Ready for the Clinic? November 16, 2017 * Banner image courtesy of Dr Sally Lowell - MRC Centre for Regenerative Medicine, University of Edinburgh A research paper recently published in the Journal of Parkinson's Disease discusses an impending clinical trial in Parkinson's disease (PD) using parthenogenetic stem cells for transplantation into PD patients. Background: Stem cell breakthroughs for the treatment of PD in recent years have shown that it…
• Are Stem Cell-Based Therapies for Parkinson’s Disease Ready for the Clinic? November 16, 2017 * Banner image courtesy of Dr Sally Lowell - MRC Centre for Regenerative Medicine, University of Edinburgh A research paper recently published in the Journal of Parkinson's Disease discusses an impending clinical trial in Parkinson's disease (PD) using parthenogenetic stem cells for transplantation into PD patients. Background: Stem cell breakthroughs for the treatment of PD in recent years have shown that it…
• Are Stem Cell-Based Therapies for Parkinson’s Disease Ready for the Clinic? November 16, 2017 * Banner image courtesy of Dr Sally Lowell - MRC Centre for Regenerative Medicine, University of Edinburgh A research paper recently published in the Journal of Parkinson's Disease discusses an impending clinical trial in Parkinson's disease (PD) using parthenogenetic stem cells for transplantation into PD patients. Background: Stem cell breakthroughs for the treatment of PD in recent years have shown that it…
• Are Stem Cell-Based Therapies for Parkinson’s Disease Ready for the Clinic? November 16, 2017 * Banner image courtesy of Dr Sally Lowell - MRC Centre for Regenerative Medicine, University of Edinburgh A research paper recently published in the Journal of Parkinson's Disease discusses an impending clinical trial in Parkinson's disease (PD) using parthenogenetic stem cells for transplantation into PD patients. Background: Stem cell breakthroughs for the treatment of PD in recent years have shown that it…
• Are Stem Cell-Based Therapies for Parkinson’s Disease Ready for the Clinic? November 16, 2017 * Banner image courtesy of Dr Sally Lowell - MRC Centre for Regenerative Medicine, University of Edinburgh A research paper recently published in the Journal of Parkinson's Disease discusses an impending clinical trial in Parkinson's disease (PD) using parthenogenetic stem cells for transplantation into PD patients. Background: Stem cell breakthroughs for the treatment of PD in recent years have shown that it…
• Are Stem Cell-Based Therapies for Parkinson’s Disease Ready for the Clinic? November 16, 2017 * Banner image courtesy of Dr Sally Lowell - MRC Centre for Regenerative Medicine, University of Edinburgh A research paper recently published in the Journal of Parkinson's Disease discusses an impending clinical trial in Parkinson's disease (PD) using parthenogenetic stem cells for transplantation into PD patients. Background: Stem cell breakthroughs for the treatment of PD in recent years have shown that it…
• Are Stem Cell-Based Therapies for Parkinson’s Disease Ready for the Clinic? November 16, 2017 * Banner image courtesy of Dr Sally Lowell - MRC Centre for Regenerative Medicine, University of Edinburgh A research paper recently published in the Journal of Parkinson's Disease discusses an impending clinical trial in Parkinson's disease (PD) using parthenogenetic stem cells for transplantation into PD patients. Background: Stem cell breakthroughs for the treatment of PD in recent years have shown that it…
• Astrocytes to Dopamine Neurons in One Step June 25, 2020 Parkinson's is a neurodegenerative condition, resulting in the loss of specific types of nerve cells from the brain. The 'motor symptoms' of Parkinson's are associated with a reduction in the number of these nerve cells (or neurons) that produce the chemical 'dopamine' in the mid-brain. For a long time, researchers have been experimenting with different methods to replace these lost…
• Astrocytes to Dopamine Neurons in One Step June 25, 2020 Parkinson's is a neurodegenerative condition, resulting in the loss of specific types of nerve cells from the brain. The 'motor symptoms' of Parkinson's are associated with a reduction in the number of these nerve cells (or neurons) that produce the chemical 'dopamine' in the mid-brain. For a long time, researchers have been experimenting with different methods to replace these lost…
• Astrocytes to Dopamine Neurons in One Step June 25, 2020 Parkinson's is a neurodegenerative condition, resulting in the loss of specific types of nerve cells from the brain. The 'motor symptoms' of Parkinson's are associated with a reduction in the number of these nerve cells (or neurons) that produce the chemical 'dopamine' in the mid-brain. For a long time, researchers have been experimenting with different methods to replace these lost…
• Bayer Buys Blue Rock August 15, 2019 Last week the large pharmaceutical company Bayer announced they will be buying the biotech firm 'BlueRock Therapeutics'. This move may have important implications for the Parkinson's community. Parkinson's is characterised by the loss of dopamine neurons in the brain and for a long time scientists have been researching different methods of re-introducing these cells into the brain. One example of…
• New Purification Method May Improve Stem Cell Replacement Therapy for Parkinson’s August 28, 2018 A new process to select and purify stem cells that hold therapeutic potential to replace dopamine-producing neurons may hasten clinical development of this promising avenue to treat Parkinson’s disease. Upon being transplanted, these cells promoted dopamine production and reduced the severity of disease-related motor symptoms in an animal model of Parkinson’s disease. The pre-clinical study with that finding, “Discovery of…
• New Purification Method May Improve Stem Cell Replacement Therapy for Parkinson’s August 28, 2018 A new process to select and purify stem cells that hold therapeutic potential to replace dopamine-producing neurons may hasten clinical development of this promising avenue to treat Parkinson’s disease. Upon being transplanted, these cells promoted dopamine production and reduced the severity of disease-related motor symptoms in an animal model of Parkinson’s disease. The pre-clinical study with that finding, “Discovery of…
• hESC-Derived Dopaminergic Transplants Integrate into Basal Ganglia Circuitry in a Preclinical Model of Parkinson's Disease. September 26, 2019 hESC-Derived Dopaminergic Transplants Integrate into Basal Ganglia Circuitry in a Preclinical Model of Parkinson's Disease. Cell Rep. 2019 Sep 24;28(13):3462-3473.e5 Authors: Adler AF, Cardoso T, Nolbrant S, Mattsson B, Hoban DB, Jarl U, Wahlestedt JN, Grealish S, Björklund A, Parmar M Abstract Cell replacement is currently being explored as a therapeutic approach for neurodegenerative disease. Using stem cells as a…
• R S Macdonald Trust Awards Grant for Further Stem Cell Research August 13, 2018 The Cure Parkinson’s Trust is delighted that the R S Macdonald Charitable Trust has awarded a grant to co-fund the continuing dopamine replacement stem cell research of Dr Tilo Kunath at the Medical Research Centre in Edinburgh. This research will streamline the process of developing human embryonic stem cells into dopamine neurons, and also act as a quality-control process. The…