Genome-wide association studies of LRRK2 modifiers of Parkinson’s disease

Genome-wide association studies of LRRK2 modifiers of Parkinson’s disease
Ann Neurol. 2021 May 2. doi: 10.1002/ana.26094. Online ahead of print.ABSTRACTOBJECTIVE: The aim of this study was to search for genes/variants that modify the effect of LRRK2 mutations in terms of penetrance and age-at-onset of Parkinson's disease.METHODS: We performed the first genome-wide association study of penetrance and age-at-onset of Parkinson's disease in LRRK2 mutation carriers (776 cases and 1,103 non-cases ... read more
Source: PubMedPublished on 2021-05-03By Dongbing Lai