Glucocerebrosidase Activity is Reduced in Cryopreserved Parkinson’s Disease Patient Monocytes and Inversely Correlates with Motor Severity

Glucocerebrosidase Activity is Reduced in Cryopreserved Parkinson’s Disease Patient Monocytes and Inversely Correlates with Motor Severity
J Parkinsons Dis. 2021 Apr 26. doi: 10.3233/JPD-202508. Online ahead of print.ABSTRACTBACKGROUND: Reduced activity of lysosomal glucocerebrosidase is found in brain tissue from Parkinson's disease patients. Glucocerebrosidase is also highly expressed in peripheral blood monocytes where its activity is decreased in Parkinson's disease patients, even in the absence of GBA mutation.OBJECTIVE: To measure glucocerebrosidase activity in cryopreserved peripheral blood monocytes ... read more
Source: PubMedPublished on 2021-05-03By Laura P Hughes