GSNOR deficiency attenuates MPTP-induced neurotoxicity and autophagy by facilitating CDK5 S-nitrosation in a mouse model of Parkinson’s disease

GSNOR deficiency attenuates MPTP-induced neurotoxicity and autophagy by facilitating CDK5 S-nitrosation in a mouse model of Parkinson’s disease
Free Radic Biol Med. 2022 Jul 30:S0891-5849(22)00499-3. doi: 10.1016/j.freeradbiomed.2022.07.016. Online ahead of print.ABSTRACTThe S-nitrosoglutathione reductase (GSNOR) is a key denitrosylating enzyme that regulates protein S-nitrosation, a process which has been found to be involved in the pathogenesis of Parkinson's disease (PD). However, the physiological function of GSNOR in PD remains unknown. In a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD mouse model, we found ... read more
Source: PubMedPublished on 2022-08-02By Lijin Jiao