Hyperactive LRRK2 kinase impairs the trafficking of axonal autophagosomes

Hyperactive LRRK2 kinase impairs the trafficking of axonal autophagosomes
Autophagy. 2021 Jun 10:1-3. doi: 10.1080/15548627.2021.1936933. Online ahead of print.ABSTRACTParkinson disease (PD)-causing mutations in the LRRK2 (leucine rich repeat kinase 2) gene hyperactivate LRRK2 kinase activity. Here, we discuss our recent work linking LRRK2 hyperactivation to defective axonal autophagosome transport in neurons. In three different models, we observed that expression of the most common causative mutation for PD, LRRK2G2019S, disrupts ... read more
Source: PubMedPublished on 2021-06-10By C Alexander Boecker